Chitosan-DNA complexes: Effect of molecular parameters on the efficiency of delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F14%3A43871817" target="_blank" >RIV/70883521:28610/14:43871817 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0927775713009394" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0927775713009394</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.colsurfa.2013.12.022" target="_blank" >10.1016/j.colsurfa.2013.12.022</a>
Alternative languages
Result language
angličtina
Original language name
Chitosan-DNA complexes: Effect of molecular parameters on the efficiency of delivery
Original language description
In the last few decades, there has been a growing interest towards the use of delivery systems for a more effective treatment of various diseases and the research increasingly focused on designing innovative solutions based on intra-cellular vectors. Among them, biocompatible DNA-polyelectrolyte complexes appear as a promising strategy for in vivo delivery of biologically active macromolecules. One of the most largely employed cationic polymer is Chitosan, which is special for its biological propertiessuch as biodegradability, biocompatibility, mucoadhesivity, and permeability enhancer capacity. Due to this, complexes formed by condensation of DNA by Chitosan have been largely investigated for their potential use in gene therapy. Nevertheless the extensive efforts, the correlation between the physicochemical properties of the Chitosan-DNA polyplexes with their transfection efficiency still remains a central challenge. Moreover, the criteria and strategies for the design of efficient C
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Colloids and Surfaces A: Physicochemical and Engineering Aspects
ISSN
0927-7757
e-ISSN
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Volume of the periodical
460
Issue of the periodical within the volume
Neuveden
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
184-190
UT code for WoS article
000341880200025
EID of the result in the Scopus database
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