Cell response to PLA scaffolds functionalized with various seaweed polysaccharides

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F20%3A63526447" target="_blank" >RIV/70883521:28610/20:63526447 - isvavai.cz</a>
Result on the web
<a href="https://www.tandfonline.com/doi/abs/10.1080/00914037.2020.1798443?journalCode=gpom20" target="_blank" >https://www.tandfonline.com/doi/abs/10.1080/00914037.2020.1798443?journalCode=gpom20</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/00914037.2020.1798443" target="_blank" >10.1080/00914037.2020.1798443</a>

Result language
angličtina
Original language name
Cell response to PLA scaffolds functionalized with various seaweed polysaccharides
Original language description
The porous polylactic acid matrix has been particularly developed as a scaffold in tissue engineering, drug loading, and wound dressing. However, the loading of active chemical compounds is challenging due to its highly hydrophobic nature and lack of functional groups for chemical bonding. Plasma treatment is a fast, heat and chemical-free solution to increase its hydrophilicity by oxidative functional groups and physical etching. In this study, a highly porous PLA scaffold was obtained by polyethylene glycol pore formation agent and treated by radiofrequency (RF) air plasma. Fucoidan from Fucus vesiculosus, Macrocystis pyrifera, and Undaria pinnatifida were used to immobilize onto the activated porous PLA surface for use as medicated wound dressings. The chemical composition and morphology were investigated by FTIR, SEM-EDS analysis, and cytocompatibility assay was studied mouse embryonic fibroblast cells (NIH/3T3).
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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