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2 127 (0,075s) •

Projekt

Determining the function of an essential protein, MIX, within the cytochrome c oxidase of Kinetoplastida (KJB500960901)

T. brucei revealed that MIX is associated with several subunits of cytochrome c oxidase, implying a role in the mt respiration of Kinetoplastida cells. Our main goal is to resolve the primary function of the MIX protein wi...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 1 145 tis. Kč
    • •
  • 1 145 tis. Kč
    • •
  • AV ČR
Projekt

Genetic bases of cytochrome c oxidase deficiency (NS10581)

-encoded subunits of COX and cellular levels of copper in the biogenesis of cytochrome c oxidase complex will be studied. Analyses of the COX biogenesis......

FG - Pediatrie

  • 2009 - 2011
    • •
  • 8 608 tis. Kč
    • •
  • 8 478 tis. Kč
    • •
  • MZ
Projekt

Biogenesis and genetic defects of cytochrome c oxidase (GA303/07/0781)

Cytochrome c oxidase (COX) is the key enzyme for mitochondrial ATP production. The isolated COX defects result in severe encephalo-cardio-myopathies with poor prognosis and affect primarily children. They are mostly caused ...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 4 043 tis. Kč
    • •
  • 4 043 tis. Kč
    • •
  • GA ČR
Projekt

The role of cytochrome c oxidase subunit 4 isoforms in regulation of mitochondrial energy provision and oxidative stress (GA16-13671S)

Energy demands of mammalian organisms are mainly covered by oxidative phosphorylation apparatus located in mitochondria. Cytochrome c oxidase (COX) is a key enzyme in this process, and expression of its regulatory subunits’...

CE - Biochemie

  • 2016 - 2020
    • •
  • 6 041 tis. Kč
    • •
  • 5 735 tis. Kč
    • •
  • GA ČR
Projekt

The role of cytochrome c oxidase subunit COX6B isoforms in regulation of mitochondrial function in health and disease (GA22-21082S)

Mitochondrial cytochrome c oxidase (COX) is a key enzyme of oxidative phosphorylation (OXPHOS) system responsible for ATP production in mammalian cells. Expression of tissue-specific isoforms of COX subunits represents a cr...

Cell biology

  • 2022 - 2025
    • •
  • 7 581 tis. Kč
    • •
  • 7 581 tis. Kč
    • •
  • GA ČR
Projekt

The role of SURF1 protein in cytochrome c oxidase biogenesis (GA22-21552S)

Cytochrome c oxidase (COX) is a key enzyme of mitochondrial energetics providing ATP in mammalian cells. COX biogenesis integrates sequential assembly of 14 subunits, encoded by nuclear and mitochondrial genes. It depends o...

Biochemistry and molecular biology

  • 2022 - 2025
    • •
  • 6 933 tis. Kč
    • •
  • 6 933 tis. Kč
    • •
  • GA ČR
Projekt

Inherited mitochondrial diseases. (IZ4179)

The project is focused at molecular basis of disorders of mitochondrial energyconverting enzymes,in particular the defects of biosynthesis of cytochrome c oxidase,ATPase,and defects in mtDNA encoded subunits of NADH dehydro...

FG - Pediatrie

  • 1997 - 1999
    • •
  • 4 209 tis. Kč
    • •
  • 4 194 tis. Kč
    • •
  • MZ
Projekt

Mitochondiral diseases caused by depletion and mutation of mitochondrial DNA (ME 226)

mtDNA defects, namely depletion of mtDNA and mutations in tRNA, cytochrome c oxidase...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
    • •
  • 1 040 tis. Kč
    • •
  • 389 tis. Kč
    • •
  • MŠMT
Projekt

Genetics and molecular mechanism of cytochrome c oxidase disorders (GA303/03/0749)

Disorders of mitochondrial cytochrome c oxidase (COX), the key enzyme of cellular energy provision belong to the most severe mitochondrial diseases. Majority of selective COX defects manifest in the first months of life as ...

CE - Biochemie

  • 2003 - 2005
    • •
  • 3 576 tis. Kč
    • •
  • 3 576 tis. Kč
    • •
  • GA ČR
Projekt

Study of molecular basis of cytochrome c oxidase deficiency (GP303/03/D132)

of defects cytochrome c oxidase (COX)". The specific aim of the study...

FG - Pediatrie

  • 2003 - 2006
    • •
  • 1 511 tis. Kč
    • •
  • 1 511 tis. Kč
    • •
  • GA ČR
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