Reorganizace mitochondrie během diferenciace jednobuněčného parazita Trypanosoma brucei

Název projektu anglicky
Determining the Effectors of Mitochondrion Remodeling During Procyclic Trypanosoma brucei Differentiation
Anotace anglicky
Trypanosoma brucei is a human parasite with a complex life cycle that alternates between a mammalian host and the tsetse fly. Depending on the carbon sources available in these varied environments, this protist switches between glycolysis and oxidative phosphorylation to produce ATP. This results in the dramatic structural and metabolic remodeling of the single mitochondrion. Until recently, it was challenging to work with the various intermediate life stages, but now each of the insect vector developmental cell types can be created in vitro by simply overexpressing a single RNA binding protein. Our preliminary data with this cell line suggests that the molecular mechanisms responsible for the metabolic rewiring may be similar to what is described in cancer cells. We observe increased expression of TbIF1, the T. brucei inhibitory factor of the FoF1-ATPase, and the subsequent increase in ROS production that potentially signals a switch to aerobic glycolysis. We aim to characterize the role of several effector molecules involved in the mitochondrial remodeling during differentiation.

Kategorie VaV
ZV - Základní výzkum
CEP - hlavní obor
EE - Mikrobiologie, virologie
CEP - vedlejší obor
—
CEP - další vedlejší obor
—
OECD FORD - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
10606 - Microbiology<br>10607 - Virology

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP21-GA0-GA-R/11:1
Datum dodání záznamu
22. 2. 2021

Podobné projekty(10)