Proteolýza ve vejcích parazitických červů: úloha v patologii a její regulace

Název projektu anglicky
Proteolysis in eggs of parasitic worms: role in pathology and its regulation
Anotace anglicky
Parasites, including helminths, affect millions of people and animals worldwide and cause serious diseases. Number of these negative health and economic consequences is associated with flukes Schistosoma mansoni a Fasciola hepatica. In order to eradicate them, the development of various effective tools has to be performed. The eggs of schistosomes are the major cause of pathology by inducing tissue inflammation and granuloma formation. They secrete molecules that induce inflammation and facilitate their migration through host tissues. Eggs of Fasciola do not have pathogenic effect; however, they are important for transmission of these parasites. Egg-derived proteolytic enzymes (proteases) are supposed to play important role in host-parasite interactions. The project is focused on proteases from S. mansoni and F. hepatica eggs used as a model systems, and it will cover (1) identification of proteases by functional proteomics, (2) evaluation of their physiological role by genomic studies, and (3) their recombinant expression and biochemical characterization.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
40301 - Veterinary science
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
GJ - Choroby a škůdci zvířat, veterinární medicina

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP22-GA0-GA-R
Datum dodání záznamu
22. 2. 2022

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