Složení a funkce CII-low, alternativní formy respiračního kompexu II

Název projektu anglicky
Composition and Function of CII-low, an Alternative Assembly Form of Respiratory Complex II
Anotace anglicky
Recently we identified an alternative form of respiratory complex II (CII) that we designated CII-low. CII-low consists of the SDHA subunit associated with an incompletely defined set of its assembly factors, and becomes the dominant form of CII when mitochondrial bioenergetics is compromised. In this situation CII-low initiates metabolic reprograming that favors energy conservation at the expense of metabolic flexibility, supporting tumorigenesis in cancer cells with bioenergetics defects such as those lacking the SDHB subunit of CII. The aim of the proposed research is to fully characterize CII-low on the molecular level, define its activity and determine its role in normal CII assembly process that remains unresolved in mammalian systems. For this, we will use a combination of pharmacological and genetic approaches in cultured cells and in mice, coupled with thorough phenotypic characterization of the generated models by state-of-the-art methodology. This approach will define CII-low and provide a rationale for development of novel anticancer strategies in SDHB-deficient disease.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10608 - Biochemistry and molecular biology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
CE - Biochemie<br>EB - Genetika a molekulární biologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP22-GA0-GA-R
Datum dodání záznamu
22. 2. 2022

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