Úloha komplexu SMC5/6 a jeho interakčních partnerů v opravě poškozené DNA

Název projektu anglicky
Role of the SMC5/6 complex and its interaction partners in DNA damage repair
Anotace anglicky
Plants as sessile organisms developed several strategies to protect integrity of their genomes against genotoxic environmental stresses. The most harmful lesions induced by ionizing radiation are DNA double strand breaks (DSBs), because if unrepaired they lead to deadly karyotype instability. SMC (Structural Maintenance of Chromosomes) complexes are amongst the key factors maintaining genome integrity. Particularly, the SMC5/6 complex is involved in repair of genomic DNA. However, it is still not clear how SMC5/6 participates in DNA repair. Therefore, we aim to analyse SMC5/6 role in DNA damage repair mechanisms of the bryophyte P. patens which has efficient homologous recombination. We will also search for SMC5/6-interacting partners that direct SMC5/6 localization to sites of DNA lesions, particularly DSB. We hypothesize that SMC5/6 may interact with BRCT-containing protein(s) that binds to phosphorylated H2AX histone (which accumulates at DNA damage sites). Such SMC5/6-BRCT-H2AX interactions may mediate localization of SMC5/6 to DNA lesion sites and assist in their repair.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10611 - Plant sciences, botany
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EF - Botanika

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP23-GA0-GA-R
Datum dodání záznamu
26. 6. 2023

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