Vývoj cirkadiánních hodin v neuronech a gliích fetálního mozku a jejich citlivost k mateřskému stresu

Název projektu anglicky
Development of circadian clocks in neurons and glia of the fetal brain and their sensitivity to maternal stress
Anotace anglicky
Stress is imposed on pregnant women in their daily lives and especially in the current COVID-19 pandemic. Its effects on the developing brain increase the risk of adverse health outcomes in adulthood. Although much attention has been devoted to the study of prenatal stress, its effects on the development of circadian clocks in the fetal brain are poorly understood. Stress leads to excessive increases in glucocorticoid hormones (GCs), and we have recently shown that they affect the circadian clock in the fetal suprachiasmatic nuclei. The goal of this project is to reveal when and how clocks develop selectively in neurons and glia in specific parts of the fetal brain. We shall examine sensitivity of the fetal clocks to GCs in vitro and in vivo and using transcriptomic and proteomic approaches, we will uncover the mechanisms of their effect on the fetal clock. We will pay attention to the previously completely overlooked comparison between the two sexes. The results will provide new insights into the development of clocks in the fetal brain and their sensitivity to maternal stress.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
30105 - Physiology (including cytology)
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
ED - Fyziologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP25-GA0-GA-R
Datum dodání záznamu
21. 2. 2025

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