Fluktuace mikroprostředí kmenových buněk jako zdroj tkáňové adaptability ve zdraví a nemoci

Název projektu anglicky
Fluctuation of the stem cell niche as a source of tissue adaptability in health and disease
Anotace anglicky
Keeping our tissues functional is closely linked to their ability to renew, naturally enabled by stem cells. Although a considerable effort has been devoted to the utilization of stem cells in tissue engineering, the understanding of the real nature of stem cells in adult organism is still highly elusive. Here, we propose a new concept of stemness, based on a system of constantly fluctuating niche of cells with stem-like properties. This explains the continual readiness of tissues to adapt to an ever-changing environment. Our theory of unstable and less predictable fluid stem cell behaviour elucidates the efficient regulation of tissue homeostasis and explains the natural heterogeneity of stem cells and stemness per se. By using a unique model of the continuously growing mouse incisor combined with state-of-the-art genetic, transcriptomic and imaging methods, we will prove our preliminary data-driven hypothesis in vivo. Our concept explains the high plasticity and adaptability of tissues at the cellular and molecular level and substitutes the current deterministic view of stem cells.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10605 - Developmental biology
OECD FORD - vedlejší obor
30105 - Physiology (including cytology)
OECD FORD - další vedlejší obor
30208 - Dentistry, oral surgery and medicine
CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EB - Genetika a molekulární biologie<br>ED - Fyziologie<br>FF - ORL, oftalmologie, stomatologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP25-GA0-GA-R
Datum dodání záznamu
21. 2. 2025

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