Molekulární mechanismy kontroly kvality snRNP částic

Název projektu anglicky
Molecular mechanisms of snRNP quality control
Anotace anglicky
Small nuclear ribonucleoprotein particles (snRNPs) are key components of the spliceosome that catalyzes pre-mRNA splicing. The biogenesis of snRNP occurs in several steps, and errors in their formation underlie some hereditary diseases. In our laboratory, we have already shown that cells are able to detect incomplete and defective snRNPs and sequester them in specific cellular compartments. In this project we focus on the molecular mechanisms of snRNP quality control that discriminates between mature and incomplete/defective particles. We will specifically focus on two aspects of snRNP surveillance. We will investigate the role of the 5' cap, its methylation and factors of innate immunity that interact with the 5' end of RNA in monitoring the early steps of snRNP biogenesis. We will also test the hypothesis that coilin is a factor that specifically controls final steps of snRNP assembly. We will explore whether coilin specifically recognizes incomplete snRNPs and sequesters them in Cajal bodies, and we will investigate the molecular details of coilin interaction with snRNPs.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10608 - Biochemistry and molecular biology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
CE - Biochemie<br>EB - Genetika a molekulární biologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP24-GA0-GA-R
Datum dodání záznamu
21. 5. 2024

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