Novel function of CDK12 in regulation of functional differentiation of mammary epithelial cells

Název projektu anglicky
Novel function of CDK12 in regulation of functional differentiation of mammary epithelial cells
Anotace anglicky
Replication stress-induced DNA damage is a key trigger for functional differentiation of mammary epithelial cells into milk-secreting alveolar cells, a process involving endoreplication-driven polyploidization. Cyclin-dependent kinase 12 (CDK12) regulates transcription of DNA damage repair pathway genes and is frequently mutated in cancer, but its role in normal mammary gland biology is unexplored. Our preliminary data show that Cdk12 heterozygous mice exhibit lactation defects, and CDK12 inhibition in primary mammary epithelial cells and organoids disrupts lactogenic differentiation, reduces polyploidization, and decreases milk protein production. These findings point to a novel, essential function of CDK12 in mammary gland differentiation, which we will examine using our complementary expertise. By identifying CDK12 as a key player in normal mammary function, this work may provide critical insights into lactation failure and the origins of breast cancer linked to CDK12 mutations.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10605 - Developmental biology
OECD FORD - vedlejší obor
10601 - Cell biology
OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EA - Morfologické obory a cytologie<br>EB - Genetika a molekulární biologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP26-GA0-GA-R
Datum dodání záznamu
6. 5. 2026

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