Úloha Aire-produkujících ILC3 buněk v regulaci Th17 odpovědi

Název projektu anglicky
The role of Aire-expressing ILC3 like cells in the regulation of Th17 response
Anotace anglicky
Autoimmune regulator (Aire) plays an essential role in the induction of self-tolerant T cells during their development in the thymus by generating a mirror image of the body’s own peripheral antigen repertoire within the medullary thymic epithelial cells (mTECs). Subsequent presentation of these self-antigens by mTECs is essential for deletion of self-reactive T-cell clones and prevention of autoimmunity. Interestingly, most AIRE-mutation bearing patients suffer from candidiasis, which represents one of the most common and earliest manifestations of this mutation. Recently, we were able to show that Aire is expressed in a rare extrathymic population of MHCII positive type-3 innate lymphoid cells (ILC3) and that these Aire-ILC3 like cells regulate the Th17 response to C. albicans. This project is focused on delineating the mechanisms imposed by Aire-ILC3 like cells to regulate the Th17 response in response to extracellular pathogens or during autoimmune reaction. Together, the proposed research project should help our understanding of the Aire role in regulation of Th17 response.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
30102 - Immunology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EC - Imunologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP24-GA0-GM-R
Datum dodání záznamu
19. 2. 2024

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