Integrace virofágové DNA in vitro a in vivo

Název projektu anglicky
Virophage DNA integration in vitro and in vivo
Anotace anglicky
One of the major driving forces of evolution is horizontal gene transfer, often mediated by mobile genetic elements such as viruses. Integrases are key enzymes in this process, because they catalyze the insertion of foreign DNA into a genome. In eukaryotes, integrases are best known for their role during retrovirus infection, but homologous genes have recently been found among certain DNA viruses including Mavericks/Polintons, virophages and polinton-like viruses. Although endogenous elements related to these DNA viruses were found in the majority of protist genomes, only few viruses were isolated in culture. The ability to integrate viral DNA into the genome of the host cell has been so far experimentally shown only for the virophage mavirus, which thus represents a unique and valuable model system to study integration of DNA viruses in eukaryotes. Virophages parasitize specific lytic giant viruses and thereby protect their host cell populations. Although integration of virophages in the host genome has far-reaching ecological and evolutionary implications, it remains unexplored.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10606 - Microbiology
OECD FORD - vedlejší obor
—
OECD FORD - další vedlejší obor
—
CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EE - Mikrobiologie, virologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP24-GA0-GN-R
Datum dodání záznamu
23. 4. 2024

Podobné projekty(10)