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6 274 (0,083s) •

Projekt

Functionalization of C-H bonds in phenol compounds by tyrosinases (LTC18080)

The aim of the project is to develop new applications of tyrosinases in organic. Catechols will be prepared using two fungal tyrosinases distant in evolution (from arcularius – recombinant enzyme). The process will include 1) t...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2018 - 2020
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  • 1 921 tis. Kč
    • •
  • 1 921 tis. Kč
    • •
  • MŠMT
Projekt

Characterization and application of fungal non-heme oxidases (LD12049)

The aim of the project is to produce and characterize new non-heme oxidases of fungal origin for application in biotechnology. Focus will be on tyrosinases produced by basidiomycetes. The distribution of tyrosinases in collection cu...

EI - Biotechnologie a bionika

  • 2012 - 2015
    • •
  • 1 741 tis. Kč
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  • 1 741 tis. Kč
    • •
  • MŠMT
Projekt

Hereditary skin malignant melanoma in miniature pigs-characterization and experimental therapy (GA523/98/0229)

integrins, annexins II and VI and tyrosinase), general genetic (karyotype analysis, mapping of genes responsible for MM by DNA microsatellite polymorphism's), biochemical-glutamyltranspeptidase, alpha-mannosidase, tyrosinase

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 1998 - 2000
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  • 4 323 tis. Kč
    • •
  • 3 912 tis. Kč
    • •
  • GA ČR
Projekt

Structure of the Promoter and the 5-untranslated region of the Human Cystathionine Synthase Gene. (IZ3963)

Isolation,sequencing,and functional analysis of the promoter and the 5 -untranslated region of the human gene for cystathionine synthase is proposed.Possible defects in this gene expression will be correlated with specific...

FG - Pediatrie

  • 1997 - 1999
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  • 676 tis. Kč
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  • 676 tis. Kč
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  • MZ
Projekt

The use of human genes for metabolising enzymes in genotoxicity testing in transgenic Drosophila melanogaster (GA302/96/1393)

There are the commonly used genotoxicity tests of chemicals and environmental pollutants. Transformation of human genes for metabolising enzymes to Drosophila melanogaster which are able to detoxificate xenobiotics can increase the ...

EB - Genetika a molekulární biologie

  • 1996 - 1998
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  • 858 tis. Kč
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  • 828 tis. Kč
    • •
  • GA ČR
Projekt

Center for Functional Genetics (LC07032)

associated with development of human diseases. The gene selection will be focusedThe project is focused on functional studies of genes and their products include those with negative impact on quality of human life...

EB - Genetika a molekulární biologie

  • 2007 - 2011
    • •
  • 60 711 tis. Kč
    • •
  • 60 211 tis. Kč
    • •
  • MŠMT
Projekt

Quantitative detection of circulating melanoma cells by real-time RT-PCR in patients treated for malignant melanoma (1A8243)

The aim of the study is quantitative detection of circulating tumor cells in patients treated for melanoma with adjuvant therapy. A quantitative multimarker real-time RT-PCR assay will assess frequency of melanoma-specific markers from peripheral blo...

FO - Dermatovenerologie

  • 2004 - 2006
    • •
  • 2 335 tis. Kč
    • •
  • 2 335 tis. Kč
    • •
  • MZ
Projekt

Molecular mechanism within the Pax6 pathway controlling eye development (GA204/99/0105)

Pax6 gene is an especially interesting example of the gene controlling developmental program of the organ (eye) in organisms as divergent as human and Drosophila. Mutations in Drosophila Pax6/eyless gene as well as...

EB - Genetika a molekulární biologie

  • 1999 - 2001
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  • 3 000 tis. Kč
    • •
  • 2 591 tis. Kč
    • •
  • GA ČR
Projekt

Functional interaction between host gene regulation and the microbiome in the primate gut (LH15175)

(e.g. diet) are important drivers of gut microbiome composition in humans be controlled by host genes with specific immune functions. The project aims at tracing functional interactions between host gene regulation and the...

EE - Mikrobiologie, virologie

  • 2015 - 2017
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  • 1 997 tis. Kč
    • •
  • 1 997 tis. Kč
    • •
  • MŠMT
Projekt

Functional analysis of endogenous retroviral elements in human genome possible association with cancers (GCP305/10/J052)

transcripts or HERV-driven human genes. We plan to generate the whole transcriptome. We shall identify target transcripts of HERVs’ or HERV-driven human genes. WeWe propose an international collaborative project a...

EB - Genetika a molekulární biologie

  • 2010 - 2014
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  • 8 111 tis. Kč
    • •
  • 8 111 tis. Kč
    • •
  • GA ČR
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