Quantitative Analysis of Chemical Warfare Agents by GC/MS Method

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00007064%3AK13__%2F22%3AN0000033" target="_blank" >RIV/00007064:K13__/22:N0000033 - isvavai.cz</a>

Výsledek na webu

<a href="https://stm.bookpi.org/CTCB-V2/article/view/7121" target="_blank" >https://stm.bookpi.org/CTCB-V2/article/view/7121</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.9734/bpi/ctcb/v2/2282B" target="_blank" >10.9734/bpi/ctcb/v2/2282B</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Quantitative Analysis of Chemical Warfare Agents by GC/MS Method

Popis výsledku v původním jazyce

Analysis of hazardous chemical substances in the Czech Republic is the main task of special chemical laboratories of the Fire and Rescue Service (FRS). The general criteria and requirements for an internal standard that may be used to determine chemical warfare agents (CWAs) using the gas chromatography coupled with mass detection (GC/MS) method were established. The aim of the work was the determination CWAs on all GC/MS systems of FRS, where no CWA standards are available. The determination is based on a GC/MS analysis of a mixture of a CWA with an internal standard, conversion of the total ion current (TIC) chromatogram to extracted-ion chromatogram at a particular m/z ratio, and calculation of the CWA concentration from the internal standard concentration, response factor and chromatographic peak areas. Internal standards for seven organophosphorus nerve-paralyzing agents and four blister agents were identified, and they were verified. The gradients of the linear functions of peak area and compound concentration were used to calculate the corresponding response factors. The measurements' linearity, repeatability, and accuracy were assessed.

Název v anglickém jazyce

Quantitative Analysis of Chemical Warfare Agents by GC/MS Method

Popis výsledku anglicky

Analysis of hazardous chemical substances in the Czech Republic is the main task of special chemical laboratories of the Fire and Rescue Service (FRS). The general criteria and requirements for an internal standard that may be used to determine chemical warfare agents (CWAs) using the gas chromatography coupled with mass detection (GC/MS) method were established. The aim of the work was the determination CWAs on all GC/MS systems of FRS, where no CWA standards are available. The determination is based on a GC/MS analysis of a mixture of a CWA with an internal standard, conversion of the total ion current (TIC) chromatogram to extracted-ion chromatogram at a particular m/z ratio, and calculation of the CWA concentration from the internal standard concentration, response factor and chromatographic peak areas. Internal standards for seven organophosphorus nerve-paralyzing agents and four blister agents were identified, and they were verified. The gradients of the linear functions of peak area and compound concentration were used to calculate the corresponding response factors. The measurements' linearity, repeatability, and accuracy were assessed.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10400 - Chemical sciences

Projekt

<a href="/cs/project/VI20192022114" target="_blank" >VI20192022114: Výzkum vlastností a způsobů ochrany osob před účinky poslední generace nervově paralytických chemických látek.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Current Topics on Chemistry and Biochemistry

ISBN

978-93-5547-622-7

Počet stran výsledku

20

Strana od-do

1-19

Počet stran knihy

20

Název nakladatele

—

Místo vydání

—

Kód UT WoS kapitoly

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