Vliv variant genu pro ghrelin na úbytek tělesné hmotnosti po úpravě stravy/po zátěžové intervenci

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F07%3A00000737" target="_blank" >RIV/00023001:_____/07:00000737 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of ghrelin variants on weight loss after dietary/excercise interventions

Popis výsledku v původním jazyce

Introduction: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body s energy balance. We have analyzed the association of ghrelin variants with body weight changes after dietary/exercise intervention in healthy overweight females. Methods: Ghrelin variants Arg51 > Gln, Leu72 > Met and Gln90 > Leu were analyzed by PCR-RFLP in 80 overweight (BMI 31.1 +/- 3.0 kg/m2) females aged 25-55 years. Development of body weight and plasma lipids were analyzed in subgroups divided according to ghrelin genotypes. Results: Carriers of the Met72Met genotype were resistant to dietary/exercise intervention. They lost 1.5 kg compared to Leu72 carriers (5.3 kg). Other variants had no effect on body weight changes. Plasma lipids were not changed significantly between subgroups divided according to ghrelin variants. Conclusions: Common variants in ghrelin may have an effect on changes of body weight after behavior

Název v anglickém jazyce

Effect of ghrelin variants on weight loss after dietary/excercise interventions

Popis výsledku anglicky

Introduction: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body s energy balance. We have analyzed the association of ghrelin variants with body weight changes after dietary/exercise intervention in healthy overweight females. Methods: Ghrelin variants Arg51 > Gln, Leu72 > Met and Gln90 > Leu were analyzed by PCR-RFLP in 80 overweight (BMI 31.1 +/- 3.0 kg/m2) females aged 25-55 years. Development of body weight and plasma lipids were analyzed in subgroups divided according to ghrelin genotypes. Results: Carriers of the Met72Met genotype were resistant to dietary/exercise intervention. They lost 1.5 kg compared to Leu72 carriers (5.3 kg). Other variants had no effect on body weight changes. Plasma lipids were not changed significantly between subgroups divided according to ghrelin variants. Conclusions: Common variants in ghrelin may have an effect on changes of body weight after behavior

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NR8489" target="_blank" >NR8489: Vliv genetické variability ghrelinu na BMI v české populaci</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cor et Vasa

ISSN

0010-8650

e-ISSN

—

Svazek periodika

49

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

3

Strana od-do

213-215

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—