Varianty v genu pro ghrelin - souvislost s HDL-cholesterolem, ne však s indexem tělesné hmoty

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F07%3A00001577" target="_blank" >RIV/00023001:_____/07:00001577 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index

Popis výsledku v původním jazyce

Ghrelin is a hormone which influences eating habits, the amount of food ingested and the body's energy balance. We examined whether genetic variants in the ghrelin gene are associated with BMI, WHR and plasma lipid levels. We have evaluated the influenceof ghrelin polymorphisms (Arg51>Gln, Leu72>Met and Gln90>Leu) on BMI, WHR, and plasma lipid levels in 1,191 males and 1,368 females representatively selected from the Czech population. Anthropometrical and biochemical parameters were analysed in two different years. In the entire population, we have detected 4.8% of carriers of the Gln51 allele, 14.2% carriers of the Met72 allele, and 10.9% of the Leu90 allele. Frequencies did not differ between males and females and alleles were not in linkage disequilibrium. BMI or WHR were not influenced by variants in the ghrelin gene. The ghrelin variant Leu72>Met was associated with elevated levels of plasma HDL-cholesterol. Compared to Leu/ Leu homozygotes, the Met carriers had lower HDL-choles

Název v anglickém jazyce

Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index

Popis výsledku anglicky

Ghrelin is a hormone which influences eating habits, the amount of food ingested and the body's energy balance. We examined whether genetic variants in the ghrelin gene are associated with BMI, WHR and plasma lipid levels. We have evaluated the influenceof ghrelin polymorphisms (Arg51>Gln, Leu72>Met and Gln90>Leu) on BMI, WHR, and plasma lipid levels in 1,191 males and 1,368 females representatively selected from the Czech population. Anthropometrical and biochemical parameters were analysed in two different years. In the entire population, we have detected 4.8% of carriers of the Gln51 allele, 14.2% carriers of the Met72 allele, and 10.9% of the Leu90 allele. Frequencies did not differ between males and females and alleles were not in linkage disequilibrium. BMI or WHR were not influenced by variants in the ghrelin gene. The ghrelin variant Leu72>Met was associated with elevated levels of plasma HDL-cholesterol. Compared to Leu/ Leu homozygotes, the Met carriers had lower HDL-choles

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

—

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia biologica (Praha)

ISSN

0015-5500

e-ISSN

—

Svazek periodika

53

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

202-206

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—