In vivo 31P MR spectroscopy of human kidney grafts using the 2D-chemical shift imaging method

Kód výsledku v IS VaVaI

RIV/00023001:_____/11:00002463 - isvavai.cz

Výsledek na webu

http://dx.doi.org/10.1016/j.transproceed.2010.11.027

DOI - Digital Object Identifier

10.1016/j.transproceed.2010.11.027

Jazyk výsledku

angličtina

Název v původním jazyce

In vivo 31P MR spectroscopy of human kidney grafts using the 2D-chemical shift imaging method

Popis výsledku v původním jazyce

The aim of this work was to evaluate the possibility to use in vivo (31)P magnetic resonance spectroscopy (MRS) for the diagnosis of kidney graft dysfunction after transplantation. We examined 68 kidney grafted patients using a 1.5 T MR scanner. (31)P MRS was performed using the 2D-chemical shift imaging method. The patients were divided into 4 groups: acute rejection episode; acute tubular necrosis; late graft dysfunction; or good renal function. We measured the signal intensities of phosphomonoesters(PME), inorganic phosphate (Pi), phosphodiesters (PDE), and ?-, ?-, ?-adenosine triphosphate (ATP; with contributions of ?- and ?-adenosine diphosphate) and their ratios. Patients with an acute rejection episodes showed a significantly elevated PME/?-ATPand PDE/?-ATP, PME/Pi, and PDE/Pi signal ratios compared with the control group. The group with acute tubular necrosis had decreased ratios. Patients with late graft dysfunction revealed only an insignificant decrease in PME/Pi and PDE/P

Název v anglickém jazyce

In vivo 31P MR spectroscopy of human kidney grafts using the 2D-chemical shift imaging method

Popis výsledku anglicky

The aim of this work was to evaluate the possibility to use in vivo (31)P magnetic resonance spectroscopy (MRS) for the diagnosis of kidney graft dysfunction after transplantation. We examined 68 kidney grafted patients using a 1.5 T MR scanner. (31)P MRS was performed using the 2D-chemical shift imaging method. The patients were divided into 4 groups: acute rejection episode; acute tubular necrosis; late graft dysfunction; or good renal function. We measured the signal intensities of phosphomonoesters(PME), inorganic phosphate (Pi), phosphodiesters (PDE), and ?-, ?-, ?-adenosine triphosphate (ATP; with contributions of ?- and ?-adenosine diphosphate) and their ratios. Patients with an acute rejection episodes showed a significantly elevated PME/?-ATPand PDE/?-ATP, PME/Pi, and PDE/Pi signal ratios compared with the control group. The group with acute tubular necrosis had decreased ratios. Patients with late graft dysfunction revealed only an insignificant decrease in PME/Pi and PDE/P

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FS - Lékařská zařízení, přístroje a vybavení

OECD FORD obor

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Projekt

NT11275: In vivo fosforová MR spektroskopie při 3T

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplantation Proceedings

ISSN

0041-1345

e-ISSN

—

Svazek periodika

43

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

1570-1575

Kód UT WoS článku

000292279800033

EID výsledku v databázi Scopus

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