31P-MR spectroscopy in patients with mild and serious lower limb ischemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10381820" target="_blank" >RIV/00216208:11110/18:10381820 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.23736/S0392-9590.18.03943-3" target="_blank" >https://doi.org/10.23736/S0392-9590.18.03943-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.23736/S0392-9590.18.03943-3" target="_blank" >10.23736/S0392-9590.18.03943-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

31P-MR spectroscopy in patients with mild and serious lower limb ischemia

Popis výsledku v původním jazyce

BACKGROUND: P-31-MR spectroscopy is a technique for undertaking a comprehensive evaluation of muscle metabolism. The goal of this study was to compare patients with mild and severe lower limb ischemia measured by P-31-MR spectroscopy at rest and during exercise. METHODS: Sixteen non-diabetic mild peripheral arterial occlusive disease (PAOD) patients, 23 diabetic PAOD patients with severe ischemia and 19 healthy controls were examined by rest and dynamic P-31-MR spectroscopy with a P-31-MR system equipped with an 3T MR-compatible home-made pedal ergometer. Signal intensity ratios of phosphorous metabolites to the sum of all P-31 intensities (P-tot) and pH were obtained at rest. The PCr drop (Delta PCr), time recovery constant of PCr (tau PCr), pH at the end of the exercise (PHend), and mitochondrial capacity (Q(max)) were calculated from dynamic MR spectra. RESULTS: Diabetic PAOD patients with severe ischemia differed from controls in both rest (PCr/Pi, beta ATP/P-tot pH) and dynamic (Q(max), pH(end), tau PCr) parameters. PAOD patients with mild ischemia differed from controls only in Q(max) and PHend. Rest parameters of the non-diabefic PAOD patients did not differ from control values excluding rest pH which was higher in both patient groups. CONCLUSIONS: A combination of rest and dynamic P-31-MR spectroscopy can distinguish among all three groups of subjects. On the other hand, examination at rest is sufficient for differentiation between patient groups and verification of severe ischemia.

Název v anglickém jazyce

31P-MR spectroscopy in patients with mild and serious lower limb ischemia

Popis výsledku anglicky

BACKGROUND: P-31-MR spectroscopy is a technique for undertaking a comprehensive evaluation of muscle metabolism. The goal of this study was to compare patients with mild and severe lower limb ischemia measured by P-31-MR spectroscopy at rest and during exercise. METHODS: Sixteen non-diabetic mild peripheral arterial occlusive disease (PAOD) patients, 23 diabetic PAOD patients with severe ischemia and 19 healthy controls were examined by rest and dynamic P-31-MR spectroscopy with a P-31-MR system equipped with an 3T MR-compatible home-made pedal ergometer. Signal intensity ratios of phosphorous metabolites to the sum of all P-31 intensities (P-tot) and pH were obtained at rest. The PCr drop (Delta PCr), time recovery constant of PCr (tau PCr), pH at the end of the exercise (PHend), and mitochondrial capacity (Q(max)) were calculated from dynamic MR spectra. RESULTS: Diabetic PAOD patients with severe ischemia differed from controls in both rest (PCr/Pi, beta ATP/P-tot pH) and dynamic (Q(max), pH(end), tau PCr) parameters. PAOD patients with mild ischemia differed from controls only in Q(max) and PHend. Rest parameters of the non-diabefic PAOD patients did not differ from control values excluding rest pH which was higher in both patient groups. CONCLUSIONS: A combination of rest and dynamic P-31-MR spectroscopy can distinguish among all three groups of subjects. On the other hand, examination at rest is sufficient for differentiation between patient groups and verification of severe ischemia.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Angiology

ISSN

0392-9590

e-ISSN

—

Svazek periodika

37

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

7

Strana od-do

293-299

Kód UT WoS článku

000445302300006

EID výsledku v databázi Scopus

2-s2.0-85049397916