An AHSG gene variant modulates basal metabolic rate and body composition development after a short-time lifestyle intervention

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002502" target="_blank" >RIV/00023001:_____/11:00002502 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

An AHSG gene variant modulates basal metabolic rate and body composition development after a short-time lifestyle intervention

Popis výsledku v původním jazyce

OBJECTIVES: The AHSG (alpha2 Heremans-Schmid glycoprotein) gene is suggested to be important for the regulation of body fat and insulin sensitivity. Our study aimed to investigate the relationship between the common Thr248Met (rs4917) variant and obesitycharacteristics after an intervention with overweight females. MATERIAL AND METHODS: We analyzed 105 unrelated overweight/obese nondiabetic Czech adult females (49.0 ? 12.1 years, BMI over 28.6 kg/m2, mean BMI before intervention 32.8 ? 4.1 kg/m2) before and after 10 weeks of lifestyle modification. Biochemical and anthropometrical measurements were performed. The life style modification program consisted of a reduction of energy intake to an age-adjusted optimum and an exercise program (four units perweek). The mean weight loss was 3.2 ? 3.5 kg (3.7 ? 4.0%). RESULTS: Thr/Thr homozygotes (N=52) increased lean muscle mass (p<0.05), decreased total body fat (kg) (p<0.005) and increased basal metabolic rate (BMR) per 1 kg body weight (p<

Název v anglickém jazyce

An AHSG gene variant modulates basal metabolic rate and body composition development after a short-time lifestyle intervention

Popis výsledku anglicky

OBJECTIVES: The AHSG (alpha2 Heremans-Schmid glycoprotein) gene is suggested to be important for the regulation of body fat and insulin sensitivity. Our study aimed to investigate the relationship between the common Thr248Met (rs4917) variant and obesitycharacteristics after an intervention with overweight females. MATERIAL AND METHODS: We analyzed 105 unrelated overweight/obese nondiabetic Czech adult females (49.0 ? 12.1 years, BMI over 28.6 kg/m2, mean BMI before intervention 32.8 ? 4.1 kg/m2) before and after 10 weeks of lifestyle modification. Biochemical and anthropometrical measurements were performed. The life style modification program consisted of a reduction of energy intake to an age-adjusted optimum and an exercise program (four units perweek). The mean weight loss was 3.2 ? 3.5 kg (3.7 ? 4.0%). RESULTS: Thr/Thr homozygotes (N=52) increased lean muscle mass (p<0.05), decreased total body fat (kg) (p<0.005) and increased basal metabolic rate (BMR) per 1 kg body weight (p<

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NS10513" target="_blank" >NS10513: Účinnost dietní a pohybové intervence na kardiovaskulární riziko u centrálně obézních žen v závislosti na kandidátních genech obezity</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

32

Číslo periodika v rámci svazku

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Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

5

Strana od-do

32-36

Kód UT WoS článku

000300544200009

EID výsledku v databázi Scopus

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