Body composition changes in adult females after lifestyle intervention are influenced by the NYD-SP18 variant

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059699" target="_blank" >RIV/00023001:_____/15:00059699 - isvavai.cz</a>

Výsledek na webu

<a href="http://apps.szu.cz/svi/cejph/show_en.php?kat=obsah/2015e-sup" target="_blank" >http://apps.szu.cz/svi/cejph/show_en.php?kat=obsah/2015e-sup</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Body composition changes in adult females after lifestyle intervention are influenced by the NYD-SP18 variant

Popis výsledku v původním jazyce

Aim: The study focuses on the analysis of the possible relationship between a common NYD-SP18 (rs6971091, G >A) gene polymorphism and weight loss after lifestyle intervention (combined dietary intake and physical activity) in overweight/obese females. Methods: We genotyped 139 unrelated non-diabetic Czech females (49.5 +/- 13.3 years, average BMI at baseline 32.2 +/- 4.6 kg/m(2)). Biochemical and anthropometrical measurements were performed before and after ten weeks of lifestyle intervention. Results: The mean weight loss achieved was 4.7 +/- 3.1 kg (p< 0.01). Carriers of the NYD-SP18 GG (N = 75) genotype lost significantly more body fat mass (p = 0.04) and gained more active muscle mass (p = 0.037) than the carriers of the A allele (N = 64). After adjustment of baseline values, both differences remained significant (p = 0.03 and p = 0.016). Conclusion: Overweight/obese female carriers of the NYD-SP18 rs6971091 GG genotype exhibited a more beneficial response to the intensive lifestyle intervention than others.

Název v anglickém jazyce

Body composition changes in adult females after lifestyle intervention are influenced by the NYD-SP18 variant

Popis výsledku anglicky

Aim: The study focuses on the analysis of the possible relationship between a common NYD-SP18 (rs6971091, G >A) gene polymorphism and weight loss after lifestyle intervention (combined dietary intake and physical activity) in overweight/obese females. Methods: We genotyped 139 unrelated non-diabetic Czech females (49.5 +/- 13.3 years, average BMI at baseline 32.2 +/- 4.6 kg/m(2)). Biochemical and anthropometrical measurements were performed before and after ten weeks of lifestyle intervention. Results: The mean weight loss achieved was 4.7 +/- 3.1 kg (p< 0.01). Carriers of the NYD-SP18 GG (N = 75) genotype lost significantly more body fat mass (p = 0.04) and gained more active muscle mass (p = 0.037) than the carriers of the A allele (N = 64). After adjustment of baseline values, both differences remained significant (p = 0.03 and p = 0.016). Conclusion: Overweight/obese female carriers of the NYD-SP18 rs6971091 GG genotype exhibited a more beneficial response to the intensive lifestyle intervention than others.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Central European Journal of Public Health

ISSN

1210-7778

e-ISSN

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Svazek periodika

23

Číslo periodika v rámci svazku

Supplement S

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

"S19"-"S22"

Kód UT WoS článku

000368324000004

EID výsledku v databázi Scopus

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