Body adiposity changes after lifestyle interventions in children/adolescents and the NYD-SP18 and TMEM18 variants

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077440" target="_blank" >RIV/00023001:_____/18:00077440 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.medscimonit.com/download/index/idArt/907180" target="_blank" >https://www.medscimonit.com/download/index/idArt/907180</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.12659/MSM.907180" target="_blank" >10.12659/MSM.907180</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Body adiposity changes after lifestyle interventions in children/adolescents and the NYD-SP18 and TMEM18 variants

Popis výsledku v původním jazyce

Background: This study was carried out to determine the relationship between the common TMEM-18 (rs4854344, G&gt;T) and NYD-SP18 (rs6971091, G&gt;A) gene variants and weight loss after lifestyle interventions (increased physical activity in conjunction with optimal dietary intake) in overweight/obese children/adolescents. Material/Methods: We genotyped 684 unrelated, white, non-diabetic children (age 12.7 +/- 2.1 years, average BMI at baseline 30.66 +/- 4.80 kg/m(2)). Anthropometric and biochemical examinations were performed before and after 4 weeks of an intensive lifestyle intervention. Results: The mean weight Loss achieved was 5.20 +/- 2.02 kg (P&lt;0.001). NYDSP-18 AA homozygotes had significantly higher abdominal skinfold value before and after the intervention (both, P=0.001). No significant associations between BMI decrease and the NYD-SP18 and TMEM18 variants were found. Associations between all anthropometrical and biochemical changes and genes remained non-significant after data were adjusted for sex, age, and baseline values. Conclusions: Decreased body weight in overweight/obese children is not significantly influenced by the NYD-SP18 rs6971091 or TMEM18 rs4854344 polymorphisms.

Název v anglickém jazyce

Body adiposity changes after lifestyle interventions in children/adolescents and the NYD-SP18 and TMEM18 variants

Popis výsledku anglicky

Background: This study was carried out to determine the relationship between the common TMEM-18 (rs4854344, G&gt;T) and NYD-SP18 (rs6971091, G&gt;A) gene variants and weight loss after lifestyle interventions (increased physical activity in conjunction with optimal dietary intake) in overweight/obese children/adolescents. Material/Methods: We genotyped 684 unrelated, white, non-diabetic children (age 12.7 +/- 2.1 years, average BMI at baseline 30.66 +/- 4.80 kg/m(2)). Anthropometric and biochemical examinations were performed before and after 4 weeks of an intensive lifestyle intervention. Results: The mean weight Loss achieved was 5.20 +/- 2.02 kg (P&lt;0.001). NYDSP-18 AA homozygotes had significantly higher abdominal skinfold value before and after the intervention (both, P=0.001). No significant associations between BMI decrease and the NYD-SP18 and TMEM18 variants were found. Associations between all anthropometrical and biochemical changes and genes remained non-significant after data were adjusted for sex, age, and baseline values. Conclusions: Decreased body weight in overweight/obese children is not significantly influenced by the NYD-SP18 rs6971091 or TMEM18 rs4854344 polymorphisms.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medical science monitor

ISSN

1234-1010

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

October 20

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

7493-7498

Kód UT WoS článku

000447722800003

EID výsledku v databázi Scopus

2-s2.0-85055204969