FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10173488" target="_blank" >RIV/00216208:11110/13:10173488 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/13:00058549 RIV/00064165:_____/13:10173488

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.clinbiochem.2012.11.017" target="_blank" >http://dx.doi.org/10.1016/j.clinbiochem.2012.11.017</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinbiochem.2012.11.017" target="_blank" >10.1016/j.clinbiochem.2012.11.017</a>

Jazyk výsledku

angličtina

Název v původním jazyce

FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention

Popis výsledku v původním jazyce

Objectives: This study aimed to determine whether there is a relationship between common FTO (rs17817449) and MC4R (rs17782313) gene variants and body mass reduction or weight loss after a one-month lifestyle intervention in overweight/obese children. Design and methods: We genotyped 357 unrelated non-diabetic Czech children (age 13.7 +/- 4.9 years, average BMI at baseline 30.8 +/- 4.6 kg/m(2)). Biochemical and anthropometrical measurements were performed before and after 4 weeks of lifestyle interventions (comprising a reduction in energy intake to the age-matched optimum and a supervised exercise program consisting of 5 exercise units per day, 50 min each). Results: The mean weight loss achieved was 6.2 +/- 2.1 kg (P<0.001). Significant associationswere found between a BMI decrease and the FTO and MC4R variants. Carriers of the FTO GG genotype and/or MC4R CC genotype lost significantly more body weight compared to noncarriers (P<0.0009 for BMI and P<0.002 for body weight). These dif

Název v anglickém jazyce

FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention

Popis výsledku anglicky

Objectives: This study aimed to determine whether there is a relationship between common FTO (rs17817449) and MC4R (rs17782313) gene variants and body mass reduction or weight loss after a one-month lifestyle intervention in overweight/obese children. Design and methods: We genotyped 357 unrelated non-diabetic Czech children (age 13.7 +/- 4.9 years, average BMI at baseline 30.8 +/- 4.6 kg/m(2)). Biochemical and anthropometrical measurements were performed before and after 4 weeks of lifestyle interventions (comprising a reduction in energy intake to the age-matched optimum and a supervised exercise program consisting of 5 exercise units per day, 50 min each). Results: The mean weight loss achieved was 6.2 +/- 2.1 kg (P<0.001). Significant associationswere found between a BMI decrease and the FTO and MC4R variants. Carriers of the FTO GG genotype and/or MC4R CC genotype lost significantly more body weight compared to noncarriers (P<0.0009 for BMI and P<0.002 for body weight). These dif

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/NS10589" target="_blank" >NS10589: Genetika a faktory životního stylu u dětí s metabolickým syndromem a jejich rodinných příslušníků. Diagnostika a ovlivnění.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

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Svazek periodika

46

Číslo periodika v rámci svazku

4-5

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

313-316

Kód UT WoS článku

000315661700007

EID výsledku v databázi Scopus

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