Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00055866" target="_blank" >RIV/00023001:_____/12:00055866 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0009898112001696" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0009898112001696</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cca.2012.03.025" target="_blank" >10.1016/j.cca.2012.03.025</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study

Popis výsledku v původním jazyce

The FTO gene plays an important role in the determination of body weight and BMI and it has been suspected of being associated with all-cause mortality, cardiovascular disease, cancer and end stage renal disease, but the causal mechanism of these effectsis still unknown. One of the possibilities is the potential association with telomere length. Telomeres are repetitive DNA-sequences located at the ends of eukaryotic chromosomes' length of which is reduced in all somatic cells during ageing. Out of the908 females (3PMFs study), in 783 females both FTO 1st intron tagging polymorphism (G>T, rs17817449) and the relative telomere length were successfully analysed. The relative telomere length was calculated as the ratio of telomere repeats to single-copygene copies. The frequencies of the FTO genotypes were similar to other populations (GG = 18.3%, GT = 49.1% and TT = 32.6%). We have detected, that the relative telomere length was significantly shorter (P<0.02, P<0.01 after adjustment f

Název v anglickém jazyce

Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study

Popis výsledku anglicky

The FTO gene plays an important role in the determination of body weight and BMI and it has been suspected of being associated with all-cause mortality, cardiovascular disease, cancer and end stage renal disease, but the causal mechanism of these effectsis still unknown. One of the possibilities is the potential association with telomere length. Telomeres are repetitive DNA-sequences located at the ends of eukaryotic chromosomes' length of which is reduced in all somatic cells during ageing. Out of the908 females (3PMFs study), in 783 females both FTO 1st intron tagging polymorphism (G>T, rs17817449) and the relative telomere length were successfully analysed. The relative telomere length was calculated as the ratio of telomere repeats to single-copygene copies. The frequencies of the FTO genotypes were similar to other populations (GG = 18.3%, GT = 49.1% and TT = 32.6%). We have detected, that the relative telomere length was significantly shorter (P<0.02, P<0.01 after adjustment f

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NS10511" target="_blank" >NS10511: Vliv reprodukčního věku na citlivost cévní stěny k zevním, metabolickým a genetickým kardiovaskulárním rizikovým faktorům, longitudinální populační studie.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinica chimica acta

ISSN

0009-8981

e-ISSN

—

Svazek periodika

413

Číslo periodika v rámci svazku

15-16

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

1222-1225

Kód UT WoS článku

000305370300012

EID výsledku v databázi Scopus

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