A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F09%3A00001970" target="_blank" >RIV/00023001:_____/09:00001970 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12110/09:00010228

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies

Popis výsledku v původním jazyce

Recently, the role of the FTO gene in obesity development was described in west-European, but not in oceanic, cohorts. The objective of this study was to test the hypothesis that the FTO SNP is associated with BMI in the Slavic population and to analyzeif there could be sex-specific effects of the SNP on BMI, WHR and lipid parameters. We have analyzed three large population based samples consisting of the post-MONICA study (1191 males, 1368 females) and the 3PMFs study (908 females). FTO rs17817449 SNPwas related to BMI in males (p = 0.014). In the females from both the post-MONICA and the 3PMFs study, FTO had no effect on BMI. Sub analysis of females from the 3PMFs study demonstrated that FTO had an effect on BMI in postmenopausal (p = 0.035) but not in premenopausal females (FSH < 40 U/L was used like marker of the premenopausal status). WHR and lipid parameters were not associated with FTO in any of the analysed groups. These results suggest that, the effect of FTO SNP rs17817449

Název v anglickém jazyce

A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies

Popis výsledku anglicky

Recently, the role of the FTO gene in obesity development was described in west-European, but not in oceanic, cohorts. The objective of this study was to test the hypothesis that the FTO SNP is associated with BMI in the Slavic population and to analyzeif there could be sex-specific effects of the SNP on BMI, WHR and lipid parameters. We have analyzed three large population based samples consisting of the post-MONICA study (1191 males, 1368 females) and the 3PMFs study (908 females). FTO rs17817449 SNPwas related to BMI in males (p = 0.014). In the females from both the post-MONICA and the 3PMFs study, FTO had no effect on BMI. Sub analysis of females from the 3PMFs study demonstrated that FTO had an effect on BMI in postmenopausal (p = 0.035) but not in premenopausal females (FSH < 40 U/L was used like marker of the premenopausal status). WHR and lipid parameters were not associated with FTO in any of the analysed groups. These results suggest that, the effect of FTO SNP rs17817449

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/1M0510" target="_blank" >1M0510: Centrum výzkumu chorob srdce a cév</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical chemistry and laboratory medicine

ISSN

1434-6621

e-ISSN

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Svazek periodika

47

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

4

Strana od-do

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Kód UT WoS článku

000266014200002

EID výsledku v databázi Scopus

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