Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00056137" target="_blank" >RIV/00023001:_____/12:00056137 - isvavai.cz</a>

Výsledek na webu

<a href="http://ac.els-cdn.com/S0304383512001048/1-s2.0-S0304383512001048-main.pdf?_tid=ba790cd225de29f1197aec431ab21a5b&acdnat=1340111606_878dd5d2b0f5b9ee244ef6de9f9fa512" target="_blank" >http://ac.els-cdn.com/S0304383512001048/1-s2.0-S0304383512001048-main.pdf?_tid=ba790cd225de29f1197aec431ab21a5b&acdnat=1340111606_878dd5d2b0f5b9ee244ef6de9f9fa512</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.canlet.2012.02.004" target="_blank" >10.1016/j.canlet.2012.02.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal

Popis výsledku v původním jazyce

Calcineurin inhibitors (CNIs) may promote post-transplantation cancer through altered expression of cytokines and chemokines in tumor cells. We found that there is a potential cross-talk among CNI-induced signaling molecules and mTOR. Here, we utilized amurine model of post-transplantation cancer to examine the effect of a combination therapy (CNI+mTOR-inhibitor rapamycin) on allograft survival and renal cancer progression. The therapy prolonged allograft survival; and significantly attenuated CNI-induced post-transplantation cancer progression, with down-regulation of mTOR and S6-kinase phosphorylation. Also, rapamycin inhibited CNI-induced over-expression of the angiogenic cytokine VEGF, and the chemokine receptor CXCR3 and its ligands in post-transplantation tumor tissues.

Název v anglickém jazyce

Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal

Popis výsledku anglicky

Calcineurin inhibitors (CNIs) may promote post-transplantation cancer through altered expression of cytokines and chemokines in tumor cells. We found that there is a potential cross-talk among CNI-induced signaling molecules and mTOR. Here, we utilized amurine model of post-transplantation cancer to examine the effect of a combination therapy (CNI+mTOR-inhibitor rapamycin) on allograft survival and renal cancer progression. The therapy prolonged allograft survival; and significantly attenuated CNI-induced post-transplantation cancer progression, with down-regulation of mTOR and S6-kinase phosphorylation. Also, rapamycin inhibited CNI-induced over-expression of the angiogenic cytokine VEGF, and the chemokine receptor CXCR3 and its ligands in post-transplantation tumor tissues.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer letters

ISSN

0304-3835

e-ISSN

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Svazek periodika

321

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

8

Strana od-do

179-186

Kód UT WoS článku

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EID výsledku v databázi Scopus

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