A perivascular system releasing sirolimus prevented intimal hyperplasia in a rabbit model in a medium-term study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00056297" target="_blank" >RIV/00023001:_____/12:00056297 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/12:00385280 RIV/61389013:_____/12:00385280

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0378517312001731" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0378517312001731</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijpharm.2012.02.023" target="_blank" >10.1016/j.ijpharm.2012.02.023</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A perivascular system releasing sirolimus prevented intimal hyperplasia in a rabbit model in a medium-term study

Popis výsledku v původním jazyce

The main complication of aortocoronary reconstruction with vein grafts is restenosis in the course of time. The aim was to assess the effect of a periadventitial polyester mesh releasing sirolimus on intimal hyperplasia of autologous grafts. We implantedv. jugularis ext. into a. carotis communis in rabbits. The vein graft was either intact, or was wrapped with a pure polyester mesh, or with a sirolimus-releasing mesh. Three and six weeks after surgery, the veins were subjected to standard histologicalstaining and the thicknesses of the tunica intima, the media and the intima-media complex were measured. Wrapping the vein with a mesh releasing sirolimus or with a pure mesh decreased the thickness of the intima in comparison with a vein graft by 73 +/-11% or 73 +/- 8% after 3 weeks, and by 73 +/- 9% or 59 +/- 12% after 6 weeks, respectively. Sirolimus-releasing meshes reduced the thickness of the media by 65 +/- 9% and 20 +/- 12% after 3 and 6 weeks. The thickness of the intima-media

Název v anglickém jazyce

A perivascular system releasing sirolimus prevented intimal hyperplasia in a rabbit model in a medium-term study

Popis výsledku anglicky

The main complication of aortocoronary reconstruction with vein grafts is restenosis in the course of time. The aim was to assess the effect of a periadventitial polyester mesh releasing sirolimus on intimal hyperplasia of autologous grafts. We implantedv. jugularis ext. into a. carotis communis in rabbits. The vein graft was either intact, or was wrapped with a pure polyester mesh, or with a sirolimus-releasing mesh. Three and six weeks after surgery, the veins were subjected to standard histologicalstaining and the thicknesses of the tunica intima, the media and the intima-media complex were measured. Wrapping the vein with a mesh releasing sirolimus or with a pure mesh decreased the thickness of the intima in comparison with a vein graft by 73 +/-11% or 73 +/- 8% after 3 weeks, and by 73 +/- 9% or 59 +/- 12% after 6 weeks, respectively. Sirolimus-releasing meshes reduced the thickness of the media by 65 +/- 9% and 20 +/- 12% after 3 and 6 weeks. The thickness of the intima-media

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International journal of pharmaceutics

ISSN

0378-5173

e-ISSN

—

Svazek periodika

427

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

311-319

Kód UT WoS článku

000302364500022

EID výsledku v databázi Scopus

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