HDL and Apolipoprotein A1 concentrations as markers of cholesterol efflux in middle-aged women: interaction with smoking

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00057939" target="_blank" >RIV/00023001:_____/12:00057939 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.nel.edu/home.htm" target="_blank" >http://www.nel.edu/home.htm</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

HDL and Apolipoprotein A1 concentrations as markers of cholesterol efflux in middle-aged women: interaction with smoking

Popis výsledku v původním jazyce

OBJECTIVES: It has been demonstrated that the deleterious effect of smoking on the cardiovascular system is mediated through a decrease in protective HDL cholesterol. In addition, women are more sensitive to the negative effects of smoking, although theexact mechanism underlying this phenomenon is currently unknown. In this study, we evaluated whether smoking habits could modify the association of HDL cholesterol and apolipoprotein A1 (ApoA1) with reverse cholesterol transport (RCT), as measured by cholesterol efflux (CHE), in middle-aged women. DESIGN: The study group consisted of 39 healthy middle-aged women, 21 non-smokers (age 51.8 +/- 2.5 years, BMI 25.1 +/- 2.8 kg/m(2)) and 18 smokers (age 50.5 +/- 3.2 years, BMI 24.8 +/- 3.5 kg/m(2)). In addition to all traditional cardiovascular risk factors, CHE from macrophages, labelled during a 48-hour incubation in a medium containing [C-14] cholesterol, to plasma acceptors in study subjects was established as a marker of reverse choleste

Název v anglickém jazyce

HDL and Apolipoprotein A1 concentrations as markers of cholesterol efflux in middle-aged women: interaction with smoking

Popis výsledku anglicky

OBJECTIVES: It has been demonstrated that the deleterious effect of smoking on the cardiovascular system is mediated through a decrease in protective HDL cholesterol. In addition, women are more sensitive to the negative effects of smoking, although theexact mechanism underlying this phenomenon is currently unknown. In this study, we evaluated whether smoking habits could modify the association of HDL cholesterol and apolipoprotein A1 (ApoA1) with reverse cholesterol transport (RCT), as measured by cholesterol efflux (CHE), in middle-aged women. DESIGN: The study group consisted of 39 healthy middle-aged women, 21 non-smokers (age 51.8 +/- 2.5 years, BMI 25.1 +/- 2.8 kg/m(2)) and 18 smokers (age 50.5 +/- 3.2 years, BMI 24.8 +/- 3.5 kg/m(2)). In addition to all traditional cardiovascular risk factors, CHE from macrophages, labelled during a 48-hour incubation in a medium containing [C-14] cholesterol, to plasma acceptors in study subjects was established as a marker of reverse choleste

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/NT12170" target="_blank" >NT12170: Genetická determinace závislosti na tabáku a účinnosti odvykací léčby.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

33

Číslo periodika v rámci svazku

suppl. 2

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

5

Strana od-do

38-42

Kód UT WoS článku

000312175400008

EID výsledku v databázi Scopus

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