CD14+CD16+and CD14+CD163+monocyte subpopulations in kidney allograft transplantation
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00058834" target="_blank" >RIV/00023001:_____/14:00058834 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.biomedcentral.com/1471-2172/15/4" target="_blank" >http://www.biomedcentral.com/1471-2172/15/4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1471-2172-15-4" target="_blank" >10.1186/1471-2172-15-4</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
CD14+CD16+and CD14+CD163+monocyte subpopulations in kidney allograft transplantation
Popis výsledku v původním jazyce
Monocytes represent a heterogeneuos population of cells subdivided according to the expression level of membrane antigens. A pro-inflammatory (intermediate/nonclassical) subpopulation of monocytes is defined by expression of CD16. CD163 seems to be characteristically preferentially expressed by immunosuppressive monocytes.The aim of our study was to avaluete the distribution of monocyte subpopulations in 71 patients with kidney allograft transplantation. The phenotype was evaluated by flow cytometry indefined time points. The proportions of peripheral CD14+CD16+ monocytes were downregulated immediately after the kidney transplantation and basiliximab treatment partially attenuated this trend. The transient downregulation of the CD14+CD16+ subpopulation was adjust to basal values in two months. The proportions of CD14+Cd163+ monocytes were transietlyupregulated early after the kidney transplantation and remained higher during the first month in most patients. In ATG treated patients, t
Název v anglickém jazyce
CD14+CD16+and CD14+CD163+monocyte subpopulations in kidney allograft transplantation
Popis výsledku anglicky
Monocytes represent a heterogeneuos population of cells subdivided according to the expression level of membrane antigens. A pro-inflammatory (intermediate/nonclassical) subpopulation of monocytes is defined by expression of CD16. CD163 seems to be characteristically preferentially expressed by immunosuppressive monocytes.The aim of our study was to avaluete the distribution of monocyte subpopulations in 71 patients with kidney allograft transplantation. The phenotype was evaluated by flow cytometry indefined time points. The proportions of peripheral CD14+CD16+ monocytes were downregulated immediately after the kidney transplantation and basiliximab treatment partially attenuated this trend. The transient downregulation of the CD14+CD16+ subpopulation was adjust to basal values in two months. The proportions of CD14+Cd163+ monocytes were transietlyupregulated early after the kidney transplantation and remained higher during the first month in most patients. In ATG treated patients, t
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EC - Imunologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GAP301%2F11%2F1568" target="_blank" >GAP301/11/1568: Buněčné aspekty transplantační tolerance</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
BMC IMMUNOLOGY
ISSN
1471-2172
e-ISSN
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Svazek periodika
15
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
10
Strana od-do
1-10
Kód UT WoS článku
000332972400001
EID výsledku v databázi Scopus
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