The association between APOA5 haplotypes and plasma lipids is not modified by energy or fat intake: The Czech HAPIEE study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00058919" target="_blank" >RIV/00023001:_____/14:00058919 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/75010330:_____/14:00010719

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0939475313001993" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0939475313001993</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.numecd.2013.08.008" target="_blank" >10.1016/j.numecd.2013.08.008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The association between APOA5 haplotypes and plasma lipids is not modified by energy or fat intake: The Czech HAPIEE study

Popis výsledku v původním jazyce

Background and aims: Several smaller studies reported interactions between dietary factors and apolipoprotein A5 (APOA5) gene polymorphisms in determination of plasma lipids. We tested interactions between APOA5 haplotypes and dietary intake in determination of plasma triglycerides (TG) and other lipids. Methods and results: Participants (5487 males and females aged 45-69) were classified according to the number (0, 1, 2+) of minor APOA5 alleles (using T-1131 > C; rs662799 and Ser19 > Trp; rs3135506 polymorphisms) and into three groups of low (bottom 25%), medium (26the-75th percentile) and high (top 25%) of intake of total energy and total, saturated and polyunsaturated fats, assessed by food frequency questionnaire. The age-sex adjusted geometric means of plasma TG increased with the number of minor alleles, from 1.57 (standard error 0.01), to 1.79 (0.02) to 2.29 (0.10) mmol/L (p < 0.00001) but TG did not differ between groups with low, medium and high total energy intake (p = 0.251)

Název v anglickém jazyce

The association between APOA5 haplotypes and plasma lipids is not modified by energy or fat intake: The Czech HAPIEE study

Popis výsledku anglicky

Background and aims: Several smaller studies reported interactions between dietary factors and apolipoprotein A5 (APOA5) gene polymorphisms in determination of plasma lipids. We tested interactions between APOA5 haplotypes and dietary intake in determination of plasma triglycerides (TG) and other lipids. Methods and results: Participants (5487 males and females aged 45-69) were classified according to the number (0, 1, 2+) of minor APOA5 alleles (using T-1131 > C; rs662799 and Ser19 > Trp; rs3135506 polymorphisms) and into three groups of low (bottom 25%), medium (26the-75th percentile) and high (top 25%) of intake of total energy and total, saturated and polyunsaturated fats, assessed by food frequency questionnaire. The age-sex adjusted geometric means of plasma TG increased with the number of minor alleles, from 1.57 (standard error 0.01), to 1.79 (0.02) to 2.29 (0.10) mmol/L (p < 0.00001) but TG did not differ between groups with low, medium and high total energy intake (p = 0.251)

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrition, metabolism, and cardiovascular diseases

ISSN

0939-4753

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

243-247

Kód UT WoS článku

000333039300009

EID výsledku v databázi Scopus

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