Beta2-microglobulin as a diagnostic marker in cerebrospinal fluid: A Follow-Up Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059018" target="_blank" >RIV/00023001:_____/14:00059018 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/14:43908524 RIV/00064190:_____/14:#0000827

Výsledek na webu

<a href="http://www.hindawi.com/journals/dm/2014/495402/" target="_blank" >http://www.hindawi.com/journals/dm/2014/495402/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/495402" target="_blank" >10.1155/2014/495402</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Beta2-microglobulin as a diagnostic marker in cerebrospinal fluid: A Follow-Up Study

Popis výsledku v původním jazyce

Beta2-Microglobulin (beta 2-m) is a low molecular weight protein occurring in all body fluids. Its concentration increases in various pathologies. Increased values in cerebrospinal fluid (CSF) are ascribed to an activation of immune system. Using immunoturbidimetry, we examined concentrations of beta2-microglobulin in cerebrospinal fluid in a large group of 6274 patients with defined neurological diseases. Cell counts, total protein, albumin, glucose, lactic acid, immunoglobulins concentrations, and isofocusing (IEF) were also evaluated. We found substantial changes of CSF beta 2-m concentrations in purulent meningitis, leptomeningeal metastasis, viral meningitis/encephalitis, and neuroborreliosis, while in multiple sclerosis these changes were not significant. Intrathecal synthesis and immune activation were present in these clinical entities. A new normative study enables better understanding of beta2-microglobulin behavior in CSF.

Název v anglickém jazyce

Beta2-microglobulin as a diagnostic marker in cerebrospinal fluid: A Follow-Up Study

Popis výsledku anglicky

Beta2-Microglobulin (beta 2-m) is a low molecular weight protein occurring in all body fluids. Its concentration increases in various pathologies. Increased values in cerebrospinal fluid (CSF) are ascribed to an activation of immune system. Using immunoturbidimetry, we examined concentrations of beta2-microglobulin in cerebrospinal fluid in a large group of 6274 patients with defined neurological diseases. Cell counts, total protein, albumin, glucose, lactic acid, immunoglobulins concentrations, and isofocusing (IEF) were also evaluated. We found substantial changes of CSF beta 2-m concentrations in purulent meningitis, leptomeningeal metastasis, viral meningitis/encephalitis, and neuroborreliosis, while in multiple sclerosis these changes were not significant. Intrathecal synthesis and immune activation were present in these clinical entities. A new normative study enables better understanding of beta2-microglobulin behavior in CSF.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Disease markers

ISSN

0278-0240

e-ISSN

—

Svazek periodika

2014

Číslo periodika v rámci svazku

may

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

495402

Kód UT WoS článku

000335971100001

EID výsledku v databázi Scopus

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