Lucifensins, the insect defensins of biomedical importance: The story behind maggot therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059082" target="_blank" >RIV/00023001:_____/14:00059082 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388963:_____/14:00435583

Výsledek na webu

<a href="http://www.mdpi.com/1424-8247/7/3/251" target="_blank" >http://www.mdpi.com/1424-8247/7/3/251</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ph7030251" target="_blank" >10.3390/ph7030251</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lucifensins, the insect defensins of biomedical importance: The story behind maggot therapy

Popis výsledku v původním jazyce

Defensins are the most widespread antimicrobial peptides characterised in insects. These cyclic peptides, 4-6 kDa in size, are folded into alfa-helical/beta-sheet mixed structures and have a common conserved motif of three intramolecular disulfide bridges with a Cys1-Cys4, Cys2-Cys5 and Cys3-Cys6 connectivity. They have the ability to kill especially Gram-positive bacteria and some fungi, but Gram-negative bacteria are more resistant against them. Among them are the medicinally important compounds lucifensin and lucifensin II, which have recently been identified in the medicinal larvae of the blowflies Lucilia sericata and Lucilia cuprina, respectively. These defensins contribute to wound healing during a procedure known as maggot debridement therapy (MDT) which is routinely used at hospitals worldwide. Here we discuss the decades-long story of the effort to isolate and characterise these two defensins from the bodies of medicinal larvae or from their secretions/excretions. Furthermore

Název v anglickém jazyce

Lucifensins, the insect defensins of biomedical importance: The story behind maggot therapy

Popis výsledku anglicky

Defensins are the most widespread antimicrobial peptides characterised in insects. These cyclic peptides, 4-6 kDa in size, are folded into alfa-helical/beta-sheet mixed structures and have a common conserved motif of three intramolecular disulfide bridges with a Cys1-Cys4, Cys2-Cys5 and Cys3-Cys6 connectivity. They have the ability to kill especially Gram-positive bacteria and some fungi, but Gram-negative bacteria are more resistant against them. Among them are the medicinally important compounds lucifensin and lucifensin II, which have recently been identified in the medicinal larvae of the blowflies Lucilia sericata and Lucilia cuprina, respectively. These defensins contribute to wound healing during a procedure known as maggot debridement therapy (MDT) which is routinely used at hospitals worldwide. Here we discuss the decades-long story of the effort to isolate and characterise these two defensins from the bodies of medicinal larvae or from their secretions/excretions. Furthermore

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/GA203%2F08%2F0536" target="_blank" >GA203/08/0536: Antimikrobiální peptidy z hmyzu pro možná terapeutická využití</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pharmaceuticals [online]

ISSN

1424-8247

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

14

Strana od-do

251-264

Kód UT WoS článku

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EID výsledku v databázi Scopus

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