Sterol regulatory element binding protein 2 overexpression is associated with reduced adipogenesis and ectopic fat accumulation in transgenic spontaneously hypertensive rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059109" target="_blank" >RIV/00023001:_____/14:00059109 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/14:00437658

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/63/63_587.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/63/63_587.pdf</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Sterol regulatory element binding protein 2 overexpression is associated with reduced adipogenesis and ectopic fat accumulation in transgenic spontaneously hypertensive rats

Popis výsledku v původním jazyce

It has been reported that the major function of the sterol regulatory element binding protein 2 (SREBP-2) is to activate preferentially cholesterol biosynthesis in liver and adipose tissue rather than fatty acid synthesis. In the current study, we analyzed the effects of overexpression of human dominantpositive SREBP-2 transgene under control of PEPCK promoter in the spontaneously hypertensive rat (SHR) on lipid and glucose metabolism. Transgenic overexpression of SREBP-2 was associated with significantly higher hepatic triglycerides (20.4 +/- 0.9 vs. 17.0 +/- 0.05 mu mol/g, P < 0.05) but not cholesterol (10.6 +/- 0.4 vs. 10.9 +/- 0.4 mu mol/g) and decreased relative weight of epididymal fat pad (0.73 +/- 0.03 vs. 0.83. 0.03, P < 0.05). In addition, muscle triglyceride (15.8 +/- 3.7 vs. 8.5 +/- 1.2 mu mol/g, P < 0.001) and cholesterol (3.6 +/- 0.5 vs. 2.1 +/- 0.1 mu mol/g, P < 0.05) concentrations were significantly increased in transgenic rats when compared to SHR controls. Ectopic fa

Název v anglickém jazyce

Sterol regulatory element binding protein 2 overexpression is associated with reduced adipogenesis and ectopic fat accumulation in transgenic spontaneously hypertensive rats

Popis výsledku anglicky

It has been reported that the major function of the sterol regulatory element binding protein 2 (SREBP-2) is to activate preferentially cholesterol biosynthesis in liver and adipose tissue rather than fatty acid synthesis. In the current study, we analyzed the effects of overexpression of human dominantpositive SREBP-2 transgene under control of PEPCK promoter in the spontaneously hypertensive rat (SHR) on lipid and glucose metabolism. Transgenic overexpression of SREBP-2 was associated with significantly higher hepatic triglycerides (20.4 +/- 0.9 vs. 17.0 +/- 0.05 mu mol/g, P < 0.05) but not cholesterol (10.6 +/- 0.4 vs. 10.9 +/- 0.4 mu mol/g) and decreased relative weight of epididymal fat pad (0.73 +/- 0.03 vs. 0.83. 0.03, P < 0.05). In addition, muscle triglyceride (15.8 +/- 3.7 vs. 8.5 +/- 1.2 mu mol/g, P < 0.001) and cholesterol (3.6 +/- 0.5 vs. 2.1 +/- 0.1 mu mol/g, P < 0.05) concentrations were significantly increased in transgenic rats when compared to SHR controls. Ectopic fa

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

<a href="/cs/project/LH12061" target="_blank" >LH12061: Odhalení molekulární a funkční podstaty patofyziologických fenotypů u spontánně hypertenzních potkanů</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological research

ISSN

0862-8408

e-ISSN

—

Svazek periodika

63

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

587-590

Kód UT WoS článku

000345590100008

EID výsledku v databázi Scopus

—