Gender-based differences in the effect of dietary cholesterol in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F12%3A%230001702" target="_blank" >RIV/00027014:_____/12:#0001702 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.vuzv.cz/sites/File/_privat/12147.pdf" target="_blank" >http://www.vuzv.cz/sites/File/_privat/12147.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11535-012-0091-7" target="_blank" >10.2478/s11535-012-0091-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gender-based differences in the effect of dietary cholesterol in rats

Popis výsledku v původním jazyce

Male and female rats were fed diets supplemented with cholesterol and palm fat at 10 and 50 g/kg, respectively; serum, hepatic tissue and faeces were analysed. Cholesterol supplementation significantly increased serum and hepatic cholesterol both in maleand female rats. Male and female rats fed the cholesterol-containing diet differed significantly in serum cholesterol concentration (2.48 A mu mol/mL vs 2.92 A mu mol/mL), concentration of serum triacylglycerols, but not in hepatic cholesterol concentration. The serum and hepatic cholesterol concentrations correlated non-significantly in male rats (r=0.491; P=0.063) and significantly in female rats (r=0.818; P < 0.001). Cholesterol supplementation non-significantly decreased relative expression of thehepatic LDL receptor gene and significantly increased relative expression of the hepatic cholesterol 7 alpha-hydroxylase gene in rats of both genders. The faeces of control rats contained similar amounts of cholesterol and bile acids. Cho

Název v anglickém jazyce

Gender-based differences in the effect of dietary cholesterol in rats

Popis výsledku anglicky

Male and female rats were fed diets supplemented with cholesterol and palm fat at 10 and 50 g/kg, respectively; serum, hepatic tissue and faeces were analysed. Cholesterol supplementation significantly increased serum and hepatic cholesterol both in maleand female rats. Male and female rats fed the cholesterol-containing diet differed significantly in serum cholesterol concentration (2.48 A mu mol/mL vs 2.92 A mu mol/mL), concentration of serum triacylglycerols, but not in hepatic cholesterol concentration. The serum and hepatic cholesterol concentrations correlated non-significantly in male rats (r=0.491; P=0.063) and significantly in female rats (r=0.818; P < 0.001). Cholesterol supplementation non-significantly decreased relative expression of thehepatic LDL receptor gene and significantly increased relative expression of the hepatic cholesterol 7 alpha-hydroxylase gene in rats of both genders. The faeces of control rats contained similar amounts of cholesterol and bile acids. Cho

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GH - Výživa hospodářských zvířat

OECD FORD obor

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Projekt

<a href="/cs/project/GAP503%2F11%2F2479" target="_blank" >GAP503/11/2479: Inhibice intestinální absorpce sterolů hydrofobně modifikovanými polysacharidy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Central European Journal of Biology

ISSN

1895-104X

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

7

Strana od-do

980-986

Kód UT WoS článku

000309685100004

EID výsledku v databázi Scopus

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