Magnetic La1-xSrxMnO3 nanoparticles as contrast agents for MRI: the parameters affecting H-1 transverse relaxation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059352" target="_blank" >RIV/00023001:_____/15:00059352 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs11051-014-2848-6" target="_blank" >http://link.springer.com/article/10.1007%2Fs11051-014-2848-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11051-014-2848-6" target="_blank" >10.1007/s11051-014-2848-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Magnetic La1-xSrxMnO3 nanoparticles as contrast agents for MRI: the parameters affecting H-1 transverse relaxation

Popis výsledku v původním jazyce

Magnetic nanoparticles of the La1-xSrxMnO3 perovskite phase (x = 0.20-0.45) were synthesized by a sol-gel method followed by thermal and mechanical treatments. The particles were coated with a uniform silica shell, and differential centrifugation yielded a product with high colloidal stability in water. X-ray powder diffraction (XRD) data showed that the mechanical processing did not affect the lattice parameters of the magnetic cores but only reduced their mean size d(XRD). The magnetic properties of the bare particles were mainly controlled by the chemical composition and were also affected by the size of the particles. Subsequent silica coating led to an effective decrease in magnetization. Relaxometry measurements were focused primarily on colloids using magnetic cores of the same size (d(XRD) approximate to 20 nm) and different compositions, and coated with a shell measuring approximately 20 nm in thickness. The exceedingly high transverse relaxivities [r(2-)(20 degrees C) = 290-430 s(-1) mmol(-1) L at B-0 = 0.5 T] of the samples exhibited pronounced temperature dependence and correlated very well with the magnetic data. Additional samples differing in the size of the cores and silica shell thickness were prepared as well to analyze the effect of the particles on H-1 transverse relaxation. The results suggest that the dominant regime of transverse relaxation is the static dephasing regime.

Název v anglickém jazyce

Magnetic La1-xSrxMnO3 nanoparticles as contrast agents for MRI: the parameters affecting H-1 transverse relaxation

Popis výsledku anglicky

Magnetic nanoparticles of the La1-xSrxMnO3 perovskite phase (x = 0.20-0.45) were synthesized by a sol-gel method followed by thermal and mechanical treatments. The particles were coated with a uniform silica shell, and differential centrifugation yielded a product with high colloidal stability in water. X-ray powder diffraction (XRD) data showed that the mechanical processing did not affect the lattice parameters of the magnetic cores but only reduced their mean size d(XRD). The magnetic properties of the bare particles were mainly controlled by the chemical composition and were also affected by the size of the particles. Subsequent silica coating led to an effective decrease in magnetization. Relaxometry measurements were focused primarily on colloids using magnetic cores of the same size (d(XRD) approximate to 20 nm) and different compositions, and coated with a shell measuring approximately 20 nm in thickness. The exceedingly high transverse relaxivities [r(2-)(20 degrees C) = 290-430 s(-1) mmol(-1) L at B-0 = 0.5 T] of the samples exhibited pronounced temperature dependence and correlated very well with the magnetic data. Additional samples differing in the size of the cores and silica shell thickness were prepared as well to analyze the effect of the particles on H-1 transverse relaxation. The results suggest that the dominant regime of transverse relaxation is the static dephasing regime.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of nanoparticle research

ISSN

1388-0764

e-ISSN

—

Svazek periodika

17

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

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Kód UT WoS článku

000352165900001

EID výsledku v databázi Scopus

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