Geometric ring annuloplasty as an adjunct to aortic valve repair: clinical investigation of the HAART 300 device

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059842" target="_blank" >RIV/00023001:_____/16:00059842 - isvavai.cz</a>

Výsledek na webu

<a href="http://ejcts.oxfordjournals.org/content/49/3/987.full.pdf+html" target="_blank" >http://ejcts.oxfordjournals.org/content/49/3/987.full.pdf+html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ejcts/ezv234" target="_blank" >10.1093/ejcts/ezv234</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Geometric ring annuloplasty as an adjunct to aortic valve repair: clinical investigation of the HAART 300 device

Popis výsledku v původním jazyce

This study assessed the safety and efficacy of an internal geometric annuloplasty ring in a regulatory trial of aortic valve reconstruction (ClinicalTrials.gov Identifier: NCT01400841). Sixty-five patients with predominant moderate-to-severe trileaflet aortic insufficiency (AI) underwent aortic valve repair with an average age of 63 +/- 13 years (mean +/- SD). All had initial implantation of an internal aortic annuloplasty ring to correct annular dilatation and facilitate leaflet reconstruction. Leaflet plication was performed for prolapse in 80% of patients, and more complex leaflet procedures, usually employing autologous pericardium, were required in 22%. Ascending aortic and/or root aneurysms were replaced in 62%. Follow-up was for a maximum of 3 years and a mean of 2 years. No in-hospital operative mortalities, major complications or early or late valve-related events occurred. The annular diameter before repair was 26.5 +/- 2.3 mm, and the average ring diameter used was 21.5 +/- 1.6 mm. The preoperative AI grade (0-4) was 2.9 +/- 0.8 and improved after repair to 0.6 +/- 0.7 (P < 0.0001), as did the NYHA class. The mean valve gradient was 8.6 +/- 4.3 mmHg, and at 3 years, the Kaplan-Meier survival rate was 95%, with no valve-related mortality. Over the 3 years, aortic valve replacement was required in 7 patients (10.8%) for reasons usually related to surgical technique. Most repair failures occurred early, and results stabilized after 6 months. No structural complications of the rings were observed. Geometric ring annuloplasty was a safe and effective adjunct to aortic valve repair. Initial correction of annular dilatation seemed to facilitate overall reconstruction. Because most early repair failures were technical, increasing experience with geometric ring annuloplasty for aortic valve reconstruction has the potential to standardize and improve outcomes.

Název v anglickém jazyce

Geometric ring annuloplasty as an adjunct to aortic valve repair: clinical investigation of the HAART 300 device

Popis výsledku anglicky

This study assessed the safety and efficacy of an internal geometric annuloplasty ring in a regulatory trial of aortic valve reconstruction (ClinicalTrials.gov Identifier: NCT01400841). Sixty-five patients with predominant moderate-to-severe trileaflet aortic insufficiency (AI) underwent aortic valve repair with an average age of 63 +/- 13 years (mean +/- SD). All had initial implantation of an internal aortic annuloplasty ring to correct annular dilatation and facilitate leaflet reconstruction. Leaflet plication was performed for prolapse in 80% of patients, and more complex leaflet procedures, usually employing autologous pericardium, were required in 22%. Ascending aortic and/or root aneurysms were replaced in 62%. Follow-up was for a maximum of 3 years and a mean of 2 years. No in-hospital operative mortalities, major complications or early or late valve-related events occurred. The annular diameter before repair was 26.5 +/- 2.3 mm, and the average ring diameter used was 21.5 +/- 1.6 mm. The preoperative AI grade (0-4) was 2.9 +/- 0.8 and improved after repair to 0.6 +/- 0.7 (P < 0.0001), as did the NYHA class. The mean valve gradient was 8.6 +/- 4.3 mmHg, and at 3 years, the Kaplan-Meier survival rate was 95%, with no valve-related mortality. Over the 3 years, aortic valve replacement was required in 7 patients (10.8%) for reasons usually related to surgical technique. Most repair failures occurred early, and results stabilized after 6 months. No structural complications of the rings were observed. Geometric ring annuloplasty was a safe and effective adjunct to aortic valve repair. Initial correction of annular dilatation seemed to facilitate overall reconstruction. Because most early repair failures were technical, increasing experience with geometric ring annuloplasty for aortic valve reconstruction has the potential to standardize and improve outcomes.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European journal of cardio-thoracic surgery

ISSN

1010-7940

e-ISSN

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Svazek periodika

49

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

987-993

Kód UT WoS článku

000372977500047

EID výsledku v databázi Scopus

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