Catheter ablation of atrial fibrillation in elderly population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00076338" target="_blank" >RIV/00023001:_____/17:00076338 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641643/pdf/jgc-14-09-563.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641643/pdf/jgc-14-09-563.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.11909/j.issn.1671-5411.2017.09.008" target="_blank" >10.11909/j.issn.1671-5411.2017.09.008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Catheter ablation of atrial fibrillation in elderly population

Popis výsledku v původním jazyce

Background Although elderly patients have been included in published series of catheter ablation for atrial fibrillation (AF), clinical benefit and safety remain still less defined in this population. A retrospective analysis of the results of catheter ablation for AF in a large volume center focused on comparison of elderly patients with the rest of the patient cohort was conducted in this study. Methods Consecutive patients who underwent catheter ablation for AF between January 2001 and December 2016 were analysed. A total population of 3197 patients was dichotomized by the age of 70 years (394 elderly vs. 2803 younger subjects). Patients were followed in terms of arrhythmia status and survival for a median period of 18 vs. 21 and 35 vs. 57 months, respectively. Results Elderly patients were more frequently females (49%) vs. 29%, P&lt; 0.0001), had a history of hypertension (79% vs. 57%, P&lt; 0.0001), diabetes (16% vs. 11%, P&lt; 0.01), stroke (9% vs. 6%, P&lt; 0.01), coronary/peripheral artery disease (14% vs. 8%,P&lt; 0.0001), and CHA(2)DS(2)-VASc score (3.1 +/- 1.3 vs. 1.5 +/- 1.2 s, P&lt; 0.0001). Major complications were more frequent in elderly (5.3% vs. 3.2%, P = 0.03); however, this difference was driven by vascular complications (3.6% vs. 1.9%, P = 0.04). There were comparable rates of cerebrovascular (0.3 vs. 0.3%) or nonvascular complications (1.8 vs. 1.2%). Good arrhythmia control was inferior in elderly patients as compared with the rest of the cohort, both without and with antiarrhythmic drugs: 44.2%&gt;vs. 58.2%o (P&lt; 0.0001) and 78.2 vs. 83 .2% (P&lt; 0.01), respectively. Poor arrhythmia control was associated with relative risk of all-cause mortality of 2.7 (95% CI: 1.1-6.4) in elderly patients and 1.4 (95%) CI: 0.9-2.0) in younger subjects. Conclusions Catheter ablation for AF in elderly patients is safe although somewhat less effective. Good arrhythmia control is associated with better survival, especially in elderly patients.

Název v anglickém jazyce

Catheter ablation of atrial fibrillation in elderly population

Popis výsledku anglicky

Background Although elderly patients have been included in published series of catheter ablation for atrial fibrillation (AF), clinical benefit and safety remain still less defined in this population. A retrospective analysis of the results of catheter ablation for AF in a large volume center focused on comparison of elderly patients with the rest of the patient cohort was conducted in this study. Methods Consecutive patients who underwent catheter ablation for AF between January 2001 and December 2016 were analysed. A total population of 3197 patients was dichotomized by the age of 70 years (394 elderly vs. 2803 younger subjects). Patients were followed in terms of arrhythmia status and survival for a median period of 18 vs. 21 and 35 vs. 57 months, respectively. Results Elderly patients were more frequently females (49%) vs. 29%, P&lt; 0.0001), had a history of hypertension (79% vs. 57%, P&lt; 0.0001), diabetes (16% vs. 11%, P&lt; 0.01), stroke (9% vs. 6%, P&lt; 0.01), coronary/peripheral artery disease (14% vs. 8%,P&lt; 0.0001), and CHA(2)DS(2)-VASc score (3.1 +/- 1.3 vs. 1.5 +/- 1.2 s, P&lt; 0.0001). Major complications were more frequent in elderly (5.3% vs. 3.2%, P = 0.03); however, this difference was driven by vascular complications (3.6% vs. 1.9%, P = 0.04). There were comparable rates of cerebrovascular (0.3 vs. 0.3%) or nonvascular complications (1.8 vs. 1.2%). Good arrhythmia control was inferior in elderly patients as compared with the rest of the cohort, both without and with antiarrhythmic drugs: 44.2%&gt;vs. 58.2%o (P&lt; 0.0001) and 78.2 vs. 83 .2% (P&lt; 0.01), respectively. Poor arrhythmia control was associated with relative risk of all-cause mortality of 2.7 (95% CI: 1.1-6.4) in elderly patients and 1.4 (95%) CI: 0.9-2.0) in younger subjects. Conclusions Catheter ablation for AF in elderly patients is safe although somewhat less effective. Good arrhythmia control is associated with better survival, especially in elderly patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of geriatric cardiology

ISSN

1671-5411

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CN - Čínská lidová republika

Počet stran výsledku

6

Strana od-do

563-568

Kód UT WoS článku

000418531400004

EID výsledku v databázi Scopus

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