Donor PNPLA3 rs738409 genotype is a risk factor for graft steatosis. A post-transplant biopsy-based study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00076898" target="_blank" >RIV/00023001:_____/18:00076898 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1590865818301282?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1590865818301282?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.dld.2017.12.030" target="_blank" >10.1016/j.dld.2017.12.030</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Donor PNPLA3 rs738409 genotype is a risk factor for graft steatosis. A post-transplant biopsy-based study

Popis výsledku v původním jazyce

Background &amp; aims: The rs738409 c.444C &gt; G (p.I148M) polymorphism in PNPLA3 is a major factor predisposing to non-alcoholic fatty liver disease. The aim of the study was to clarify the impact of liver and extrahepatic expression of the PNPLA3 p.148M variant on liver graft steatosis after liver transplantation. Methods: Fat content was assessed in liver biopsies from 176 transplant recipients. During a period of 4 +/- 1 years after transplantation, 17 patients developed grade 3 steatosis, 14 patients grade 2 steatosis, 56 patients grade 1 steatosis, and 89 patients grade 0 steatosis. The influence of the recipient and donor rs738409 genotype and clinical and laboratory data on liver fat content were analyzed using ordinal logistic regression. Results: The PNPLA3 rs738409 CC/CG/GG genotype frequencies, respectively, were 0.494/0.449/0.057 in the graft donors and 0.545/0.330/0.125 in the graft recipients. In the multivariate analysis, the presence of the PNPLA3 c.444G allele in donor (OR 1.62; 95% CI 1.12-2.33), post-transplant BMI (OR 1.14; 95% CI 1.07-1.22), diabetes mellitus (OR 1.99; 95% CI 1.22-3.22), and serum triglycerides (OR 1.40; 95% CI 1.11-1.76) were independent risk factors for increased liver graft fat content. Conclusions: These data indicate that the liver expression of the PNPLA3 p.148M variant confers a genetic predisposition to liver graft steatosis along with nutritional status and diabetes.

Název v anglickém jazyce

Donor PNPLA3 rs738409 genotype is a risk factor for graft steatosis. A post-transplant biopsy-based study

Popis výsledku anglicky

Background &amp; aims: The rs738409 c.444C &gt; G (p.I148M) polymorphism in PNPLA3 is a major factor predisposing to non-alcoholic fatty liver disease. The aim of the study was to clarify the impact of liver and extrahepatic expression of the PNPLA3 p.148M variant on liver graft steatosis after liver transplantation. Methods: Fat content was assessed in liver biopsies from 176 transplant recipients. During a period of 4 +/- 1 years after transplantation, 17 patients developed grade 3 steatosis, 14 patients grade 2 steatosis, 56 patients grade 1 steatosis, and 89 patients grade 0 steatosis. The influence of the recipient and donor rs738409 genotype and clinical and laboratory data on liver fat content were analyzed using ordinal logistic regression. Results: The PNPLA3 rs738409 CC/CG/GG genotype frequencies, respectively, were 0.494/0.449/0.057 in the graft donors and 0.545/0.330/0.125 in the graft recipients. In the multivariate analysis, the presence of the PNPLA3 c.444G allele in donor (OR 1.62; 95% CI 1.12-2.33), post-transplant BMI (OR 1.14; 95% CI 1.07-1.22), diabetes mellitus (OR 1.99; 95% CI 1.22-3.22), and serum triglycerides (OR 1.40; 95% CI 1.11-1.76) were independent risk factors for increased liver graft fat content. Conclusions: These data indicate that the liver expression of the PNPLA3 p.148M variant confers a genetic predisposition to liver graft steatosis along with nutritional status and diabetes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30213 - Transplantation

Projekt

<a href="/cs/project/NV15-26906A" target="_blank" >NV15-26906A: Genetický, transkriptomický a metabolický profil pacientů po transplantaci jater ve vztahu k rozvoji NAFLD/NASH.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Digestive and liver disease

ISSN

1590-8658

e-ISSN

—

Svazek periodika

50

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

490-495

Kód UT WoS článku

000429911700011

EID výsledku v databázi Scopus

2-s2.0-85041009361