Independent effect of atrial fibrillation on natriuretic peptide release

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00077643" target="_blank" >RIV/00023001:_____/19:00077643 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00392-018-1332-1" target="_blank" >https://link.springer.com/article/10.1007/s00392-018-1332-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00392-018-1332-1" target="_blank" >10.1007/s00392-018-1332-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Independent effect of atrial fibrillation on natriuretic peptide release

Popis výsledku v původním jazyce

Background: We investigated whether the increase of plasma natriuretic peptides (NPs) in atrial fibrillation (AF) is independent of the effect of AF on the left atrial (LA) hemodynamics. Methods: Hemodynamically stable patients scheduled for AF ablation underwent assessment of B-type natriuretic peptide (BNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP), echocardiography, and direct measurement of left atrial (LA) pressure. Concentrations of the NPs were compared between patients in AF (n=31) and controls in sinus rhythm (SR; n=31) who were matched for age, gender, heart rate, left ventricular ejection fraction, LA volume index, and directly measured mean LA pressure. Eighteen patients underwent serial measurement of NPs and LA pressure during native SR and after 20min of pacing-induced AF. Results: Compared to the patients in SR, the patients in AF had 2.6 times higher unadjusted BNP [median (inter-quartile range), 101 (63, 129) vs. 38 (26, 79) ng/L] and two times higher unadjusted MR-proANP [183 (140, 230) vs. 91 (67, 135) pmol/L; both p&lt;0.001]. Concentrations of both NPs correlated with mean LA pressure in the patients in SR (r=0.75 for BNP and 0.62 for MR-proANP, both p&lt;0.001) but not in the patients in AF (r=0.18 and 0.04, respectively, both p&gt;0.3). Both NPs increased significantly during induced AF [adjusted median (IQR) relative change, BNP: 27 (22; 40)%, MR-proANP: 75 (64; 99)%, both p&lt;0.001] without a significant change in the LA pressure.Conclusions: The increase of NPs in AF was independent of its effect on the LA hemodynamics.

Název v anglickém jazyce

Independent effect of atrial fibrillation on natriuretic peptide release

Popis výsledku anglicky

Background: We investigated whether the increase of plasma natriuretic peptides (NPs) in atrial fibrillation (AF) is independent of the effect of AF on the left atrial (LA) hemodynamics. Methods: Hemodynamically stable patients scheduled for AF ablation underwent assessment of B-type natriuretic peptide (BNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP), echocardiography, and direct measurement of left atrial (LA) pressure. Concentrations of the NPs were compared between patients in AF (n=31) and controls in sinus rhythm (SR; n=31) who were matched for age, gender, heart rate, left ventricular ejection fraction, LA volume index, and directly measured mean LA pressure. Eighteen patients underwent serial measurement of NPs and LA pressure during native SR and after 20min of pacing-induced AF. Results: Compared to the patients in SR, the patients in AF had 2.6 times higher unadjusted BNP [median (inter-quartile range), 101 (63, 129) vs. 38 (26, 79) ng/L] and two times higher unadjusted MR-proANP [183 (140, 230) vs. 91 (67, 135) pmol/L; both p&lt;0.001]. Concentrations of both NPs correlated with mean LA pressure in the patients in SR (r=0.75 for BNP and 0.62 for MR-proANP, both p&lt;0.001) but not in the patients in AF (r=0.18 and 0.04, respectively, both p&gt;0.3). Both NPs increased significantly during induced AF [adjusted median (IQR) relative change, BNP: 27 (22; 40)%, MR-proANP: 75 (64; 99)%, both p&lt;0.001] without a significant change in the LA pressure.Conclusions: The increase of NPs in AF was independent of its effect on the LA hemodynamics.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical research in cardiology

ISSN

1861-0684

e-ISSN

—

Svazek periodika

108

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

142-149

Kód UT WoS článku

000457491800003

EID výsledku v databázi Scopus

2-s2.0-85050826851