Bronchoalveolar lavage cell profiles and proteins concentrations can be used to phenotype extrinsic allergic alveolitis patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00077800" target="_blank" >RIV/00023001:_____/19:00077800 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064190:_____/19:N0000072

Výsledek na webu

<a href="https://mrmjournal.biomedcentral.com/track/pdf/10.1186/s40248-019-0175-6" target="_blank" >https://mrmjournal.biomedcentral.com/track/pdf/10.1186/s40248-019-0175-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40248-019-0175-6" target="_blank" >10.1186/s40248-019-0175-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bronchoalveolar lavage cell profiles and proteins concentrations can be used to phenotype extrinsic allergic alveolitis patients

Popis výsledku v původním jazyce

Background Extrinsic allergic alveolitis (EAA) patients form heterogenous group with different clinical manifestation and different prognosis. We aimed to determine how to phenotype distinct EAA subgroups. Predictive role of the bronchoalveolar lavage fluid (BALF) IL-4R concentration at the time of diagnosis with regard to the clinical behavior in EAA patients was studied. Methods Concentrations of MMP-7, IL-4R, TNF-, and PAR-2 were measured in the BALF od 71 EAA patients at the time of diagnosis. Lung functions and outcome data were assessed at 12months after the diagnosis. Correlations between the BALF protein concentration, cell profile, lung functions and patient outcome were determined.Results We found positive correlations between BALF IL-4R concentration and BALF eosinophils (p=0,006), negative correlation between IL-4R BALF concentration and diffusing capacity (DLco) (p=0,003), negative correlation between IL-4R BALF concentration and forced vital capacity (FVC) (p=0,004) and negative correlation between IL-4R concentration and BALF lymphocytes (p=0,04). The BALF concentration of IL-4R was significantly higher in acute exacerbation patients (p=0,0032) and in patients progressing despite corticosteroid treatment (p=0,04). We observed a positive correlation between MMP-7 BALF concentration and the BALF lymphocytes (p=0.05), negative correlation between the PAR-2 BALF concentration and DLco (p=0.04) and a negative correlation between the BALF TNF- concentration and DLco (p=0.03). Conclusions Specific subgroup of EAA patients with more severe functional impact, distinct BALF cell profile and higher IL-4R BALF concentration can be differentiated. Correlations between the BALF concentrations of PAR-2, MMP-7 and TNF- with clinical parameters may reflect the role of inflammation in the pathogenesis of EAA.

Název v anglickém jazyce

Bronchoalveolar lavage cell profiles and proteins concentrations can be used to phenotype extrinsic allergic alveolitis patients

Popis výsledku anglicky

Background Extrinsic allergic alveolitis (EAA) patients form heterogenous group with different clinical manifestation and different prognosis. We aimed to determine how to phenotype distinct EAA subgroups. Predictive role of the bronchoalveolar lavage fluid (BALF) IL-4R concentration at the time of diagnosis with regard to the clinical behavior in EAA patients was studied. Methods Concentrations of MMP-7, IL-4R, TNF-, and PAR-2 were measured in the BALF od 71 EAA patients at the time of diagnosis. Lung functions and outcome data were assessed at 12months after the diagnosis. Correlations between the BALF protein concentration, cell profile, lung functions and patient outcome were determined.Results We found positive correlations between BALF IL-4R concentration and BALF eosinophils (p=0,006), negative correlation between IL-4R BALF concentration and diffusing capacity (DLco) (p=0,003), negative correlation between IL-4R BALF concentration and forced vital capacity (FVC) (p=0,004) and negative correlation between IL-4R concentration and BALF lymphocytes (p=0,04). The BALF concentration of IL-4R was significantly higher in acute exacerbation patients (p=0,0032) and in patients progressing despite corticosteroid treatment (p=0,04). We observed a positive correlation between MMP-7 BALF concentration and the BALF lymphocytes (p=0.05), negative correlation between the PAR-2 BALF concentration and DLco (p=0.04) and a negative correlation between the BALF TNF- concentration and DLco (p=0.03). Conclusions Specific subgroup of EAA patients with more severe functional impact, distinct BALF cell profile and higher IL-4R BALF concentration can be differentiated. Correlations between the BALF concentrations of PAR-2, MMP-7 and TNF- with clinical parameters may reflect the role of inflammation in the pathogenesis of EAA.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30203 - Respiratory systems

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Multidisciplinary respiratory medicine

ISSN

2049-6958

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

March 12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

"art. no. 13"

Kód UT WoS článku

000461046400001

EID výsledku v databázi Scopus

2-s2.0-85062889199