PAR-2, IL-4R, TGF-beta and TNF-alpha in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis

Kód výsledku v IS VaVaI

RIV/68407700:21340/14:00223770 - isvavai.cz

Nalezeny alternativní kódy

RIV/67985823:_____/14:00432081 RIV/00216208:11120/14:43908579 RIV/00064190:_____/14:#0000798

Výsledek na webu

http://dx.doi.org/10.3892/etm.2014.1776

DOI - Digital Object Identifier

10.3892/etm.2014.1776

Jazyk výsledku

angličtina

Název v původním jazyce

PAR-2, IL-4R, TGF-beta and TNF-alpha in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis

Popis výsledku v původním jazyce

Sarcoidosis (SARC) and extrinsic allergic alveolitis (EAA) share certain markers, making a differential diagnosis difficult even with histopathological investigation. In lung tissue, proteinase-activated receptor-2 (PAR-2) is primarily investigated withregard to epithelial and inflammatory perspectives. Varying levels of certain chemokines can be a useful tool for distinguishing EAA and SARC. Thus, in the present study, differences in the levels of transforming growth factor (TGF)-beta 1, tumor necrosis factor (TNF)-alpha, interleukin-4 receptor (IL-4R) and PAR-2 in bronchoalveolar lavage fluid (BALF) were compared, using an ELISA method, between 14 patients with EAA and six patients with SARC. Statistically significant higher levels of IL-4R, PAR-2 and the PAR-2/TGF-beta 1 and PAR-2/TNF-alpha ratios were observed in EAA patients as compared with SARC patients. Furthermore, the ratios of TNF-alpha/total protein, TGF-beta 1/PAR-2 and TNF-alpha/PAR-2 were significantly lower in EAA pati

Název v anglickém jazyce

PAR-2, IL-4R, TGF-beta and TNF-alpha in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis

Popis výsledku anglicky

Sarcoidosis (SARC) and extrinsic allergic alveolitis (EAA) share certain markers, making a differential diagnosis difficult even with histopathological investigation. In lung tissue, proteinase-activated receptor-2 (PAR-2) is primarily investigated withregard to epithelial and inflammatory perspectives. Varying levels of certain chemokines can be a useful tool for distinguishing EAA and SARC. Thus, in the present study, differences in the levels of transforming growth factor (TGF)-beta 1, tumor necrosis factor (TNF)-alpha, interleukin-4 receptor (IL-4R) and PAR-2 in bronchoalveolar lavage fluid (BALF) were compared, using an ELISA method, between 14 patients with EAA and six patients with SARC. Statistically significant higher levels of IL-4R, PAR-2 and the PAR-2/TGF-beta 1 and PAR-2/TNF-alpha ratios were observed in EAA patients as compared with SARC patients. Furthermore, the ratios of TNF-alpha/total protein, TGF-beta 1/PAR-2 and TNF-alpha/PAR-2 were significantly lower in EAA pati

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

NT13433: Imunopatogenetický podklad fibrogeneze u intersticiálních plicních procesů, biomarkery fibrogeneze

Návaznosti

S - Specificky vyzkum na vysokych skolach
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EXPERIMENTAL AND THERAPEUTIC MEDICINE

ISSN

1792-0981

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

6

Strana od-do

533-538

Kód UT WoS článku

000339127500034

EID výsledku v databázi Scopus

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