Mid-term clinical outcomes of out-of-hospital cardiac arrest patients treated with targeted temperature management at 34-36 degrees C versus 32-34 degrees C

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078045" target="_blank" >RIV/00023001:_____/19:00078045 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/19:43917442

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S014795631830284X?token=5657B17D444308B3329C3D8EA834C7B787E46AC1F0A0BD903466B4B417F785B262B67E98ADB7BF976EDC438CAA247131" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S014795631830284X?token=5657B17D444308B3329C3D8EA834C7B787E46AC1F0A0BD903466B4B417F785B262B67E98ADB7BF976EDC438CAA247131</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.hrtlng.2018.11.007" target="_blank" >10.1016/j.hrtlng.2018.11.007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mid-term clinical outcomes of out-of-hospital cardiac arrest patients treated with targeted temperature management at 34-36 degrees C versus 32-34 degrees C

Popis výsledku v původním jazyce

Background: Targeted temperature management (TTM) in comatose survivors of out-of-hospital cardiac arrest has been associated with improved neurological outcomes. However, the optimal temperature target for TTM remains unclear. Objectives: To compare a um protocol targeted at 34-36 degrees C with a protocol targeted at 32-34 degrees C with reference to both clinical outcomes and acute complications. Methods: We analyzed a prospective registry of consecutive out-of-hospital cardiac arrest survivors who underwent TTM. We compared patients on a TTM protocol targeted at 34-36 degrees C (n- 59) with a historical cohort of patients treated at 32-34 degrees C (n-116) according to the following parameters: six-month survival, cerebral performance category (CPC) scores, and acute complications. Results: Survival and favorable neurological outcomes (CPC &lt;= 2) at six months were 56% and 49%, respectively, in the higher target temperature group vs. 66% and 61%, respectively, in the lower target temperature group (p = 0.18 and 0.13). Acute clinical complications occurred in 1.5% vs. 12% of patients treated at the higher vs. the lower temperature range (p = 0.02). Conclusions: Patients treated with TTM at 34-36 degrees C had similar mid-term survival and neurological outcomes as patients treated with TTM at 32-34 degrees C. However, patients treated within the higher temperature range had fewer acute complications. (C) 2018 Elsevier Inc. All rights reserved.

Název v anglickém jazyce

Mid-term clinical outcomes of out-of-hospital cardiac arrest patients treated with targeted temperature management at 34-36 degrees C versus 32-34 degrees C

Popis výsledku anglicky

Background: Targeted temperature management (TTM) in comatose survivors of out-of-hospital cardiac arrest has been associated with improved neurological outcomes. However, the optimal temperature target for TTM remains unclear. Objectives: To compare a um protocol targeted at 34-36 degrees C with a protocol targeted at 32-34 degrees C with reference to both clinical outcomes and acute complications. Methods: We analyzed a prospective registry of consecutive out-of-hospital cardiac arrest survivors who underwent TTM. We compared patients on a TTM protocol targeted at 34-36 degrees C (n- 59) with a historical cohort of patients treated at 32-34 degrees C (n-116) according to the following parameters: six-month survival, cerebral performance category (CPC) scores, and acute complications. Results: Survival and favorable neurological outcomes (CPC &lt;= 2) at six months were 56% and 49%, respectively, in the higher target temperature group vs. 66% and 61%, respectively, in the lower target temperature group (p = 0.18 and 0.13). Acute clinical complications occurred in 1.5% vs. 12% of patients treated at the higher vs. the lower temperature range (p = 0.02). Conclusions: Patients treated with TTM at 34-36 degrees C had similar mid-term survival and neurological outcomes as patients treated with TTM at 32-34 degrees C. However, patients treated within the higher temperature range had fewer acute complications. (C) 2018 Elsevier Inc. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Heart and lung

ISSN

0147-9563

e-ISSN

—

Svazek periodika

48

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

273-277

Kód UT WoS článku

000473374900003

EID výsledku v databázi Scopus

2-s2.0-85058215688