Time to start of cardiopulmonary resuscitation and the effect of target temperature management at 33 degrees C and 36 degrees C

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10325177" target="_blank" >RIV/00064165:_____/16:10325177 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10325177

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.resuscitation.2015.10.013" target="_blank" >http://dx.doi.org/10.1016/j.resuscitation.2015.10.013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.resuscitation.2015.10.013" target="_blank" >10.1016/j.resuscitation.2015.10.013</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Time to start of cardiopulmonary resuscitation and the effect of target temperature management at 33 degrees C and 36 degrees C

Popis výsledku v původním jazyce

Introduction: The optimal temperature during targeted temperature management (TTM) for comatose patients resuscitated from out-of-hospital cardiac arrest is unknown. It has been hypothesized that patients with long no-flow times, for example those without bystander CPR would have the most to gain from temperature management at lower temperatures. Methods: We analysed data from an international clinical trial randomizing cardiac arrest patients to targeted temperature management at 33 degrees C and 36 degrees C for an interaction between no-flow time and intervention group, with neurological function at six months after cardiac arrest as the primary outcome. A cerebral performance category (CPC) score of 1 or 2 was considered a good outcome. Results: No-flow time (min) was associated with poor neurological outcome (OR 1.13, 95% confidence interval 1.06-1.20, p < 0.001). There was no statistically significant interaction between no flow-time and intervention group (p = 0.11), which may imply that the non-superior effect of 33 degrees C was consistent for all no-flow times. Bystander CPR was not independently associated with neurological function. Conclusions: TTM at 33 degrees C compared to 36 degrees C was not associated with an increased probability of a good neurological function for patients with longer no-flow times.

Název v anglickém jazyce

Time to start of cardiopulmonary resuscitation and the effect of target temperature management at 33 degrees C and 36 degrees C

Popis výsledku anglicky

Introduction: The optimal temperature during targeted temperature management (TTM) for comatose patients resuscitated from out-of-hospital cardiac arrest is unknown. It has been hypothesized that patients with long no-flow times, for example those without bystander CPR would have the most to gain from temperature management at lower temperatures. Methods: We analysed data from an international clinical trial randomizing cardiac arrest patients to targeted temperature management at 33 degrees C and 36 degrees C for an interaction between no-flow time and intervention group, with neurological function at six months after cardiac arrest as the primary outcome. A cerebral performance category (CPC) score of 1 or 2 was considered a good outcome. Results: No-flow time (min) was associated with poor neurological outcome (OR 1.13, 95% confidence interval 1.06-1.20, p < 0.001). There was no statistically significant interaction between no flow-time and intervention group (p = 0.11), which may imply that the non-superior effect of 33 degrees C was consistent for all no-flow times. Bystander CPR was not independently associated with neurological function. Conclusions: TTM at 33 degrees C compared to 36 degrees C was not associated with an increased probability of a good neurological function for patients with longer no-flow times.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Resuscitation

ISSN

0300-9572

e-ISSN

—

Svazek periodika

99

Číslo periodika v rámci svazku

February

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

6

Strana od-do

44-49

Kód UT WoS článku

000370180700017

EID výsledku v databázi Scopus

2-s2.0-84954338677