Clinical predictors of complications in patients with left-sided infective endocarditis: A retrospective study of 206 episodes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078114" target="_blank" >RIV/00023001:_____/19:00078114 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/19:10395653 RIV/00216208:11150/19:10395653 RIV/00179906:_____/19:10395653

Výsledek na webu

<a href="http://www.elis.sk/download_file.php?product_id=6240&session_id=gvgcob1dg3u7vuk2vnfp43j311" target="_blank" >http://www.elis.sk/download_file.php?product_id=6240&session_id=gvgcob1dg3u7vuk2vnfp43j311</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2019_082" target="_blank" >10.4149/BLL_2019_082</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clinical predictors of complications in patients with left-sided infective endocarditis: A retrospective study of 206 episodes

Popis výsledku v původním jazyce

PURPOSE: Early identification of specific patient subgroups at high risk of developing life-threatening infective endocarditis (IE) complications is of paramount importance. Better stratification may allow more intensive treatment of these patients and positively influences clinical outcomes. METHODS: We carried out a retrospective survey of consecutive left-sided IE adult patients, admitted over a 15-year period to two main tertiary care centres in the Czech Republic. RESULTS: Among a group of 196 patients (155 males; median age 64 years), a total of 206 left-sided IE episodes were identified. Perivalvular extension of infection was most frequently seen in prosthetic aortic valve endocarditis (OR 6.706, p&lt;0.0001). Valve prolapse/perforation during IE episodes was significantly associated with mitral valve IE (OR 2.136, p=0.026) and vegetation length (OR 1.055, p=0.009). Septic shock was significantly related to two main risk factors: S. aureus infection (OR 8.459, p=&lt;0.0001) and smoking (OR 8.403, p=0.001). Mitral valve IE with a vegetation length &gt;= 13 mm was the strongest risk factor for this complication (OR 3.24, p=0.001), followed by S. aureus infection (OR 3.59, p=0.002). Finally, septic shock (OR 6.000, p=0.001) represented the most important risk factor of in-hospital mortality. CONCLUSIONS: This study provides the most detailed profile of complication predictors related to left-sided IE in Central Europe. Early individual stratification of IE related occurrence of complications might help to decrease extremely high morbidity and mortality of this disease (Tab. 5, Ref. 37).

Název v anglickém jazyce

Clinical predictors of complications in patients with left-sided infective endocarditis: A retrospective study of 206 episodes

Popis výsledku anglicky

PURPOSE: Early identification of specific patient subgroups at high risk of developing life-threatening infective endocarditis (IE) complications is of paramount importance. Better stratification may allow more intensive treatment of these patients and positively influences clinical outcomes. METHODS: We carried out a retrospective survey of consecutive left-sided IE adult patients, admitted over a 15-year period to two main tertiary care centres in the Czech Republic. RESULTS: Among a group of 196 patients (155 males; median age 64 years), a total of 206 left-sided IE episodes were identified. Perivalvular extension of infection was most frequently seen in prosthetic aortic valve endocarditis (OR 6.706, p&lt;0.0001). Valve prolapse/perforation during IE episodes was significantly associated with mitral valve IE (OR 2.136, p=0.026) and vegetation length (OR 1.055, p=0.009). Septic shock was significantly related to two main risk factors: S. aureus infection (OR 8.459, p=&lt;0.0001) and smoking (OR 8.403, p=0.001). Mitral valve IE with a vegetation length &gt;= 13 mm was the strongest risk factor for this complication (OR 3.24, p=0.001), followed by S. aureus infection (OR 3.59, p=0.002). Finally, septic shock (OR 6.000, p=0.001) represented the most important risk factor of in-hospital mortality. CONCLUSIONS: This study provides the most detailed profile of complication predictors related to left-sided IE in Central Europe. Early individual stratification of IE related occurrence of complications might help to decrease extremely high morbidity and mortality of this disease (Tab. 5, Ref. 37).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

—

Svazek periodika

120

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

6

Strana od-do

510-515

Kód UT WoS článku

000475423100005

EID výsledku v databázi Scopus

2-s2.0-85073114186