The number and phenotype of myocardial and adipose tissue CD68+ cells is associated with cardiovascular and metabolic disease in heart surgery patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078224" target="_blank" >RIV/00023001:_____/19:00078224 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10396489 RIV/00064165:_____/19:10396489

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S0939475319302133?token=4749186315B040DAF6ECF29D602BE5A227FAC824F608041B794164779D18B1B68059A2A831496091DE50AEBE9AE54EA5" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0939475319302133?token=4749186315B040DAF6ECF29D602BE5A227FAC824F608041B794164779D18B1B68059A2A831496091DE50AEBE9AE54EA5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.numecd.2019.05.063" target="_blank" >10.1016/j.numecd.2019.05.063</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The number and phenotype of myocardial and adipose tissue CD68+ cells is associated with cardiovascular and metabolic disease in heart surgery patients

Popis výsledku v původním jazyce

Background and aims: CD68+ cells are a potent source of inflammatory cytokines in adipose tissue and myocardium. The development of low-grade inflammation in adipose tissue is implicated in the pathogenesis of obesity-associated disorders including type 2 diabetes mellitus (T2DM) and cardiovascular disease. The main aim of the study was to characterize and quantify myocardial and adipose tissue CD68+ cells and adipose tissue crown-like structures (CLS) in patients with obesity, coronary artery disease (CAD) and T2DM. Methods and results: Samples were obtained from the right atrium, epicardial (EAT) and subcutaneous adipose tissue (SAT) during elective heart surgery (non-obese, n = 34 patients; obese, n = 24 patients). Immunohistochemistry was used to visualize CD68+ cells. M1-polarized macrophages were visualized by immunohistochemical detection of CD11c. The proportion of CD68+ cells was higher in EAT than in SAT (43.4 +/- 25.0 versus 32.5 +/- 23.1 cells per 1 mm(2); p = 0.015). Myocardial CD68+ cells were more abundant in obese patients (45.6 +/- 24.5 versus 27.7 +/- 14.8 cells per 1 mm(2); p = 0.045). In SAT, CD68+ cells were more frequent in CAD patients (37.3 +/- 23.0 versus 23.1 +/- 20.9 cells per 1 mm(2); p = 0.012). Patients having CLS in their SAT had higher average BMI (34.1 +/- 6.4 versus 29.0 +/- 4.5; p = 0.024). Conclusions: Regional-based increases in the frequency of CD68+ cells and changes of their phenotype in CLS were detected in obese patients and CAD patients. Therapeutic modulation of adipose tissue inflammation may represent a target for treatment of obesity. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Název v anglickém jazyce

The number and phenotype of myocardial and adipose tissue CD68+ cells is associated with cardiovascular and metabolic disease in heart surgery patients

Popis výsledku anglicky

Background and aims: CD68+ cells are a potent source of inflammatory cytokines in adipose tissue and myocardium. The development of low-grade inflammation in adipose tissue is implicated in the pathogenesis of obesity-associated disorders including type 2 diabetes mellitus (T2DM) and cardiovascular disease. The main aim of the study was to characterize and quantify myocardial and adipose tissue CD68+ cells and adipose tissue crown-like structures (CLS) in patients with obesity, coronary artery disease (CAD) and T2DM. Methods and results: Samples were obtained from the right atrium, epicardial (EAT) and subcutaneous adipose tissue (SAT) during elective heart surgery (non-obese, n = 34 patients; obese, n = 24 patients). Immunohistochemistry was used to visualize CD68+ cells. M1-polarized macrophages were visualized by immunohistochemical detection of CD11c. The proportion of CD68+ cells was higher in EAT than in SAT (43.4 +/- 25.0 versus 32.5 +/- 23.1 cells per 1 mm(2); p = 0.015). Myocardial CD68+ cells were more abundant in obese patients (45.6 +/- 24.5 versus 27.7 +/- 14.8 cells per 1 mm(2); p = 0.045). In SAT, CD68+ cells were more frequent in CAD patients (37.3 +/- 23.0 versus 23.1 +/- 20.9 cells per 1 mm(2); p = 0.012). Patients having CLS in their SAT had higher average BMI (34.1 +/- 6.4 versus 29.0 +/- 4.5; p = 0.024). Conclusions: Regional-based increases in the frequency of CD68+ cells and changes of their phenotype in CLS were detected in obese patients and CAD patients. Therapeutic modulation of adipose tissue inflammation may represent a target for treatment of obesity. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NV15-26854A" target="_blank" >NV15-26854A: Význam epikardiální tukové tkáně u onemocnění srdce: nové mechanizmy působení a jejich terapeutické ovlivnění</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrition, metabolism, and cardiovascular diseases

ISSN

0939-4753

e-ISSN

—

Svazek periodika

29

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

946-955

Kód UT WoS článku

000478962200007

EID výsledku v databázi Scopus

2-s2.0-85068787562