Baseline Leptin/Adiponectin Ratio is a Significant Predictor of BMI Changes in Children/Adolescents after Intensive Lifestyle Intervention

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078649" target="_blank" >RIV/00023001:_____/19:00078649 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10401092 RIV/00064165:_____/19:10401092

Výsledek na webu

<a href="https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0859-7041" target="_blank" >https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0859-7041</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1055/a-0859-7041" target="_blank" >10.1055/a-0859-7041</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Baseline Leptin/Adiponectin Ratio is a Significant Predictor of BMI Changes in Children/Adolescents after Intensive Lifestyle Intervention

Popis výsledku v původním jazyce

Introduction Abdominal obesity is a strong card iometabolic risk factor that often occurs as early as in childhood. The negative effect of abdominal obesity on the metabolism is partially mediated by changes to the production of the major adipocyte hormones leptin and adiponectin. Leptin/adiponectin imbalance is associated with increased risk of developing obesity and type 2 diabetes mellitus. Aim To determine whether leptin, adiponectin and the leptin/adiponectin ratio are significant predictors of body weight loss in intensively treated children/adolescents. Methods 183 paediatric overweight or obese patients (71 boys and 112 girls), aged 7-16 years, were enrolled in a one-month intensive lifestyle intervention programme. Participants reduced their energy intake and engaged in a supervised exercise programme consisting of 5 physical activity units per day. The subjects were examined both before and after the intervention. Results The mean BMI decrease achieved was -2.38 +/- 0.07 kg/m(2) (P &lt; 0.01). The decrease in plasma leptin concentration was - 16.59 +/- 0.84 ng/mL (P&lt;0.001) and CRP- 0.38 +/- 0.04 mg/L (P&lt;0.001). Changes in adiponectin concentrations were not statistically significant. The baseline leptin/adiponectin ratio was a significant predictor of decreases in body weight (P&lt;0.005), BMI (P&lt;0.0001) and waist circumference (P&lt;0.05). Conclusion The leptin/adiponectin ratio at baseline may be a useful predictor of results from interventions focused on decreasing BMIs in children/adolescents.

Název v anglickém jazyce

Baseline Leptin/Adiponectin Ratio is a Significant Predictor of BMI Changes in Children/Adolescents after Intensive Lifestyle Intervention

Popis výsledku anglicky

Introduction Abdominal obesity is a strong card iometabolic risk factor that often occurs as early as in childhood. The negative effect of abdominal obesity on the metabolism is partially mediated by changes to the production of the major adipocyte hormones leptin and adiponectin. Leptin/adiponectin imbalance is associated with increased risk of developing obesity and type 2 diabetes mellitus. Aim To determine whether leptin, adiponectin and the leptin/adiponectin ratio are significant predictors of body weight loss in intensively treated children/adolescents. Methods 183 paediatric overweight or obese patients (71 boys and 112 girls), aged 7-16 years, were enrolled in a one-month intensive lifestyle intervention programme. Participants reduced their energy intake and engaged in a supervised exercise programme consisting of 5 physical activity units per day. The subjects were examined both before and after the intervention. Results The mean BMI decrease achieved was -2.38 +/- 0.07 kg/m(2) (P &lt; 0.01). The decrease in plasma leptin concentration was - 16.59 +/- 0.84 ng/mL (P&lt;0.001) and CRP- 0.38 +/- 0.04 mg/L (P&lt;0.001). Changes in adiponectin concentrations were not statistically significant. The baseline leptin/adiponectin ratio was a significant predictor of decreases in body weight (P&lt;0.005), BMI (P&lt;0.0001) and waist circumference (P&lt;0.05). Conclusion The leptin/adiponectin ratio at baseline may be a useful predictor of results from interventions focused on decreasing BMIs in children/adolescents.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NV15-28876A" target="_blank" >NV15-28876A: Využití genového HTG skóre v diagnostice primárních hypertriglyceridemií a odhadu rizika gastrointestinálních a kardiovaskulárních komplikací</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental and clinical endocrinology &amp; diabetes

ISSN

0947-7349

e-ISSN

—

Svazek periodika

127

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

691-696

Kód UT WoS článku

000496758800007

EID výsledku v databázi Scopus

2-s2.0-85074545612