Dialysis therapy is associated with peripheral marginal zone B-cell augmentation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F20%3A00079644" target="_blank" >RIV/00023001:_____/20:00079644 - isvavai.cz</a>

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S0966327420300356?token=7452FC205B09E41AD1AE98D0045F1CF941F014570C93838722A396F0A92F42D537D636E4A82FF047F4B7455CCBC730AE" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0966327420300356?token=7452FC205B09E41AD1AE98D0045F1CF941F014570C93838722A396F0A92F42D537D636E4A82FF047F4B7455CCBC730AE</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.trim.2020.101289" target="_blank" >10.1016/j.trim.2020.101289</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dialysis therapy is associated with peripheral marginal zone B-cell augmentation

Popis výsledku v původním jazyce

Chronic kidney disease stage 5 (CKD5) dialysis patients who stay long term in uremic environment often exhibit several, poorly defined, immune impairments. In this study, we assessed peripheral virus-specific effector/memory cells and subpopulations of T, B and DC cells using ELISPOT and FACS methods in 74 low-risk kidney transplant candidates without anti-HLA antibodies, prior to transplantation in pre-emptive (never experienced dialysis) and dialysis cohorts. There was difference in circulating marginal zone B cells (MZB) (IgD(high)CD27(high)) between dialysis patients and those receiving kidney grafts pre-emptively (P = .002). Patients treated on dialysis &gt; 12 months had also 4.2-fold greater risk of increased absolute numbers of MZB (95%CI:1.6-11.2; P = .004). There were no other differences in B-, T- and DC-cell subsets. Numbers of effector/memory T cells reactive to major opportunistic virus-specific antigens (CMV, BKV and EBV) were not affected by dialysis. Nonsensitised dialysis-treated patients displayed significantly more circulating MZB compared to those CKD5 patients that had never undergone dialysis therapy.

Název v anglickém jazyce

Dialysis therapy is associated with peripheral marginal zone B-cell augmentation

Popis výsledku anglicky

Chronic kidney disease stage 5 (CKD5) dialysis patients who stay long term in uremic environment often exhibit several, poorly defined, immune impairments. In this study, we assessed peripheral virus-specific effector/memory cells and subpopulations of T, B and DC cells using ELISPOT and FACS methods in 74 low-risk kidney transplant candidates without anti-HLA antibodies, prior to transplantation in pre-emptive (never experienced dialysis) and dialysis cohorts. There was difference in circulating marginal zone B cells (MZB) (IgD(high)CD27(high)) between dialysis patients and those receiving kidney grafts pre-emptively (P = .002). Patients treated on dialysis &gt; 12 months had also 4.2-fold greater risk of increased absolute numbers of MZB (95%CI:1.6-11.2; P = .004). There were no other differences in B-, T- and DC-cell subsets. Numbers of effector/memory T cells reactive to major opportunistic virus-specific antigens (CMV, BKV and EBV) were not affected by dialysis. Nonsensitised dialysis-treated patients displayed significantly more circulating MZB compared to those CKD5 patients that had never undergone dialysis therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30213 - Transplantation

Projekt

<a href="/cs/project/7E13020" target="_blank" >7E13020: Personalized minimization of immunosuppression after solid organ transplantation by biomarker-driven stratification of patients to improve long-term outcome and health-economic data of transplantation</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplant immunology

ISSN

0966-3274

e-ISSN

—

Svazek periodika

60

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

"art. no .101289"

Kód UT WoS článku

000530686500006

EID výsledku v databázi Scopus

2-s2.0-85082519269