Liver stiffness measured by two-dimensional shear-wave elastography predicts hepatic vein pressure gradient at high values in liver transplant candidates with advanced liver cirrhosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080661" target="_blank" >RIV/00023001:_____/21:00080661 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/21:10421917 RIV/61383082:_____/21:00001180

Výsledek na webu

<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0244934" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0244934</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0244934" target="_blank" >10.1371/journal.pone.0244934</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Liver stiffness measured by two-dimensional shear-wave elastography predicts hepatic vein pressure gradient at high values in liver transplant candidates with advanced liver cirrhosis

Popis výsledku v původním jazyce

Liver stiffness is a reliable non-invasive predictor of Hepatic Venous Pressure Gradient (HVPG) above 10 mm Hg. However, it failed to predict higher thresholds of HVPG. Our aim was to investigate whether liver stiffness and selected previously published non-invasive blood biomarkers could predict higher HVPG thresholds in liver transplant candidates without ongoing alcohol use. One hundred and nine liver transplant candidates with liver cirrhosis of various aetiologies underwent direct HVPG measurement, liver stiffness measurement by 2D shear-wave elastography (Aixplorer Multiwave, Supersonic Imagine, France) and assessment of blood HVPG biomarkers (osteopontin, VCAM-1, IL-6, TNF-alpha, IL-1ra/IL-1F3 and ELF score). The correlation between liver stiffness and HVPG was linear up to 30 mm Hg of HVPG (r = 0.765, p &lt; 0.0001). The regression lines had similar slopes for HVPG values below and above 16 mm Hg (p &gt; 0.05) and the correlation in patients with HVPG &lt;16 mm Hg (r = 0.456, p = 0.01) was similar to patients with HVPG &gt;= 16 mm Hg (r = 0.499, p &lt; 0.0001). The correlation was similar in the subgroup patients with alcoholic (r = 0.718, p &lt; 0.0001), NASH (r = 0.740, p = 0.008), cryptogenic (r = 0.648, p = 0,0377), cholestatic and autoimmune (r = 0.706, p &lt; 0.0001) and viral cirrhosis (r = 0.756, p &lt; 0.0001). Liver stiffness distinguished patients with HVPG above 16, and 20 mm Hg with AUROCs 0.90243, and 0.86824, sensitivity 0.7656, and 0.7027, and specificity 0.9333, and 0.8750. All studied blood biomarkers correlated better with liver stiffness than with HVPG and their AUROCs did not exceed 0.8 at both HVPG thresholds. Therefore, a composite predictor superior to liver stiffness could not be established. We conclude that liver stiffness is a clinically reliable predictor of higher HVPG thresholds in non-drinking subjects with advanced liver cirrhosis.

Název v anglickém jazyce

Liver stiffness measured by two-dimensional shear-wave elastography predicts hepatic vein pressure gradient at high values in liver transplant candidates with advanced liver cirrhosis

Popis výsledku anglicky

Liver stiffness is a reliable non-invasive predictor of Hepatic Venous Pressure Gradient (HVPG) above 10 mm Hg. However, it failed to predict higher thresholds of HVPG. Our aim was to investigate whether liver stiffness and selected previously published non-invasive blood biomarkers could predict higher HVPG thresholds in liver transplant candidates without ongoing alcohol use. One hundred and nine liver transplant candidates with liver cirrhosis of various aetiologies underwent direct HVPG measurement, liver stiffness measurement by 2D shear-wave elastography (Aixplorer Multiwave, Supersonic Imagine, France) and assessment of blood HVPG biomarkers (osteopontin, VCAM-1, IL-6, TNF-alpha, IL-1ra/IL-1F3 and ELF score). The correlation between liver stiffness and HVPG was linear up to 30 mm Hg of HVPG (r = 0.765, p &lt; 0.0001). The regression lines had similar slopes for HVPG values below and above 16 mm Hg (p &gt; 0.05) and the correlation in patients with HVPG &lt;16 mm Hg (r = 0.456, p = 0.01) was similar to patients with HVPG &gt;= 16 mm Hg (r = 0.499, p &lt; 0.0001). The correlation was similar in the subgroup patients with alcoholic (r = 0.718, p &lt; 0.0001), NASH (r = 0.740, p = 0.008), cryptogenic (r = 0.648, p = 0,0377), cholestatic and autoimmune (r = 0.706, p &lt; 0.0001) and viral cirrhosis (r = 0.756, p &lt; 0.0001). Liver stiffness distinguished patients with HVPG above 16, and 20 mm Hg with AUROCs 0.90243, and 0.86824, sensitivity 0.7656, and 0.7027, and specificity 0.9333, and 0.8750. All studied blood biomarkers correlated better with liver stiffness than with HVPG and their AUROCs did not exceed 0.8 at both HVPG thresholds. Therefore, a composite predictor superior to liver stiffness could not be established. We conclude that liver stiffness is a clinically reliable predictor of higher HVPG thresholds in non-drinking subjects with advanced liver cirrhosis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

<a href="/cs/project/NV16-27546A" target="_blank" >NV16-27546A: Neinvazivní hodnocení pokročilosti jaterní cirhózy a portální hypertenze pomocí shear-wave elastografie u pacientů čekajících na transplantaci jater</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS ONE [online]

ISSN

1932-6203

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

18

Strana od-do

"art. no. e0244934"

Kód UT WoS článku

000608044300111

EID výsledku v databázi Scopus

2-s2.0-85099483194