Portal Hypertension Is the Main Driver of Liver Stiffness in Advanced Liver Cirrhosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081580" target="_blank" >RIV/00023001:_____/21:00081580 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/21:10432591

Výsledek na webu

<a href="https://www.biomed.cas.cz/physiolres/pdf/2021/70_563.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2021/70_563.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.934626" target="_blank" >10.33549/physiolres.934626</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Portal Hypertension Is the Main Driver of Liver Stiffness in Advanced Liver Cirrhosis

Popis výsledku v původním jazyce

Liver stiffness (LS) is a novel non-invasive parameter widely used in clinical hepatology. LS correlates with liver fibrosis stage in non-cirrhotic patients. In cirrhotic patients it also shows good correlation with Hepatic Venous Pressure Gradient (HVPG). Our aim was to assess the contribution of liver fibrosis and portal hypertension to LS in patients with advanced liver cirrhosis. Eighty-one liver transplant candidates with liver cirrhosis of various aetiologies underwent direct HVPG and LS measurement by 2D shear-wave elastography (Aixplorer Multiwave, Supersonic Imagine, France). Liver collagen content was assessed in the explanted liver as collagen proportionate area (CPA) and hydroxyproline content (HP). The studied cohort included predominantly patients with Child-Pugh class B and C (63/81, 77.8 %), minority of patients were Child-Pugh A (18/81, 22.2 %). LS showed the best correlation with HVPG (r=0.719, p&lt;0.001), correlation of LS with CPA (r=0.441, p&lt;0.001) and HP/Amino Acids (r=0.414, p&lt; 0.001) was weaker. Both variables expressing liver collagen content showed good correlation with each other (r=0.574, p&lt;0.001). Multiple linear regression identified the strongest association between LS and HVPG (p&lt;0.0001) and weaker association of LS with CPA (p = 0.01883). Stepwise modelling showed minimal increase in r(2) after addition of CPA to HVPG (0.5073 vs. 0.5513). The derived formula expressing LS value formation is: LS=2.48 + (1.29 x HVPG) + (0.26 x CPA). We conclude that LS is determined predominantly by HVPG in patients with advanced liver cirrhosis whereas contribution of liver collagen content is relatively low.

Název v anglickém jazyce

Portal Hypertension Is the Main Driver of Liver Stiffness in Advanced Liver Cirrhosis

Popis výsledku anglicky

Liver stiffness (LS) is a novel non-invasive parameter widely used in clinical hepatology. LS correlates with liver fibrosis stage in non-cirrhotic patients. In cirrhotic patients it also shows good correlation with Hepatic Venous Pressure Gradient (HVPG). Our aim was to assess the contribution of liver fibrosis and portal hypertension to LS in patients with advanced liver cirrhosis. Eighty-one liver transplant candidates with liver cirrhosis of various aetiologies underwent direct HVPG and LS measurement by 2D shear-wave elastography (Aixplorer Multiwave, Supersonic Imagine, France). Liver collagen content was assessed in the explanted liver as collagen proportionate area (CPA) and hydroxyproline content (HP). The studied cohort included predominantly patients with Child-Pugh class B and C (63/81, 77.8 %), minority of patients were Child-Pugh A (18/81, 22.2 %). LS showed the best correlation with HVPG (r=0.719, p&lt;0.001), correlation of LS with CPA (r=0.441, p&lt;0.001) and HP/Amino Acids (r=0.414, p&lt; 0.001) was weaker. Both variables expressing liver collagen content showed good correlation with each other (r=0.574, p&lt;0.001). Multiple linear regression identified the strongest association between LS and HVPG (p&lt;0.0001) and weaker association of LS with CPA (p = 0.01883). Stepwise modelling showed minimal increase in r(2) after addition of CPA to HVPG (0.5073 vs. 0.5513). The derived formula expressing LS value formation is: LS=2.48 + (1.29 x HVPG) + (0.26 x CPA). We conclude that LS is determined predominantly by HVPG in patients with advanced liver cirrhosis whereas contribution of liver collagen content is relatively low.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

<a href="/cs/project/NV16-27546A" target="_blank" >NV16-27546A: Neinvazivní hodnocení pokročilosti jaterní cirhózy a portální hypertenze pomocí shear-wave elastografie u pacientů čekajících na transplantaci jater</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological research

ISSN

0862-8408

e-ISSN

—

Svazek periodika

70

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

15

Strana od-do

563-577

Kód UT WoS článku

000693412000008

EID výsledku v databázi Scopus

2-s2.0-85114762715