Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080788" target="_blank" >RIV/00023001:_____/21:00080788 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00209775:_____/21:N0000019 RIV/00159816:_____/21:00074723 RIV/00064190:_____/21:N0000072 RIV/00216208:11110/21:10416587 a 3 dalších

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S0966327420301489?token=0137EA8BF6D421ACF9D70C22041C0846744314FFEDB5A4CF345B8707B112DF6E4B9ABE00DF22A5D41868B87B2F0F2E9F" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0966327420301489?token=0137EA8BF6D421ACF9D70C22041C0846744314FFEDB5A4CF345B8707B112DF6E4B9ABE00DF22A5D41868B87B2F0F2E9F</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.trim.2020.101340" target="_blank" >10.1016/j.trim.2020.101340</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

Popis výsledku v původním jazyce

Introduction: Recent studies suggested potential positive correlations between HLA-specific antibodies and development of cardiac allograft vasculopathy (CAV). Methods: This prospective two-center study investigated early progression of CAV by coronary optical coherence tomography in 1 month and 12 months after heart transplantation (HTx) in 104 patients. Detection and characterization of donor specific (DSA) and MHC class-I polypeptide-related sequence A (MICA) antibodies were performed before, 1, 6 and 12 months after transplantation. Results: During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area (P &lt;.001), and progression in mean intimal thickness (IT) (P &lt;.001). DSA and anti-MICA occurred in 17% of all patients, but no significant relationship was observed between presence of DSA/anti-MICA and IT progression within 12 months after HTx. In contrast, we observed significant association between presence of DSA (p=0.031), de-novo DSA (p=0.031), HLA Class II DSA (p=0.017) and media thickness (MT) progression. Conclusion: Results of our study did not identify a direct association between presence of DSA/anti-MICA and intimal thickness progression in an early period after HTx. However, we found significant relationships between DSA and media thickness progression that may identify a newly recognized immune-pathological aspect of CAV. © 2020 Elsevier B.V.

Název v anglickém jazyce

Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

Popis výsledku anglicky

Introduction: Recent studies suggested potential positive correlations between HLA-specific antibodies and development of cardiac allograft vasculopathy (CAV). Methods: This prospective two-center study investigated early progression of CAV by coronary optical coherence tomography in 1 month and 12 months after heart transplantation (HTx) in 104 patients. Detection and characterization of donor specific (DSA) and MHC class-I polypeptide-related sequence A (MICA) antibodies were performed before, 1, 6 and 12 months after transplantation. Results: During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area (P &lt;.001), and progression in mean intimal thickness (IT) (P &lt;.001). DSA and anti-MICA occurred in 17% of all patients, but no significant relationship was observed between presence of DSA/anti-MICA and IT progression within 12 months after HTx. In contrast, we observed significant association between presence of DSA (p=0.031), de-novo DSA (p=0.031), HLA Class II DSA (p=0.017) and media thickness (MT) progression. Conclusion: Results of our study did not identify a direct association between presence of DSA/anti-MICA and intimal thickness progression in an early period after HTx. However, we found significant relationships between DSA and media thickness progression that may identify a newly recognized immune-pathological aspect of CAV. © 2020 Elsevier B.V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30213 - Transplantation

Projekt

<a href="/cs/project/NV16-27465A" target="_blank" >NV16-27465A: Sledování koronární nemoci srdečního štěpu pomocí optické koherentní tomografie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplant immunology

ISSN

0966-3274

e-ISSN

—

Svazek periodika

65

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

"art. no. 101340"

Kód UT WoS článku

000633033800006

EID výsledku v databázi Scopus

2-s2.0-85094857312